Protein Alignment CG5846 and RFXANK

DIOPT Version :10

• Sequence 1: NP_609333.1
• Gene: CG5846 / 34326
• FlyBaseID: FBgn0032171
• Length: 234
• Species: Drosophila melanogaster
• Sequence 2: NP_001357167.1
• Gene: RFXANK / 8625
• HGNCID: 9987
• Length: 285
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 89/264 - (33%)
• Similarity: 124/264 - (46%)
• Gaps: 47/264 - (17%)

  Fly     1 MVAPA----NTIQTNAN---SDDDEGVRSAPTSMLVL---------------DAKRKSAFLPYRP 43
            :..||    .|.||.|:   ..:|.|..:|..|..|:               ||...|      |
Human     3 LTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS------P 61

  Fly    44 Q-------STVLTNLQRGNTEATFCPVEV-SLSFHERAGQGEITEEQVAAERARQQNIDYK-DAH 99
            |       ||.|||.|||| |.:..|..: |||.|:.|.|||:  :|:.....:..|:..| |..
Human    62 QAGSSLKHSTTLTNRQRGN-EVSALPATLDSLSIHQLAAQGEL--DQLKEHLRKGDNLVNKPDER 123

  Fly   100 GFTALHWAASYGQLVSVQLLVAAGANVNTMAPDLISPLLLAAAGGHNEIVRFLLEHGADSGHMDI 164
            |||.|.||:::|::.:|:.|:..||:.:.:|.:..|.|.||:.||:.:||..|||...|....|.
Human   124 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDW 188

  Fly   165 VGNTALMYAAAGNHPHTCNELLAKDLDLSATNEDGDTAYSLAV-----EHGAHLAQALLEQYMTA 224
            .|.|.|:||..|||......|||:..||:...:.|.|...|||     :.|..|....||.|  .
Human   189 NGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKDGVSLLLPRLECY--G 251

  Fly   225 IITA 228
            :|:|
Human   252 VISA 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5846	NP_609333.1	ANKYR	<92..232	CDD:440430	53/143 (37%)
		ANK repeat	99..130	CDD:293786	11/30 (37%)
		ANK repeat	132..163	CDD:293786	12/30 (40%)
		ANK repeat	165..196	CDD:293786	13/30 (43%)
RFXANK	NP_001357167.1	ANKYR	<94..244	CDD:440430	54/151 (36%)
		ANK repeat	94..121	CDD:293786	8/28 (29%)
		ANK repeat	123..154	CDD:293786	11/30 (37%)
		ANK repeat	156..187	CDD:293786	12/30 (40%)
		ANK repeat	189..217	CDD:293786	12/27 (44%)