DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5846 and Kidins220

DIOPT Version :9

Sequence 1:	NP_001303318.1	Gene:	CG5846 / 34326	FlyBaseID:	FBgn0032171	Length:	234	Species:	Drosophila melanogaster
Sequence 2:	XP_006515313.1	Gene:	Kidins220 / 77480	MGIID:	1924730	Length:	1794	Species:	Mus musculus

Alignment Length:	239	Identity:	61/239 - (25%)
Similarity:	107/239 - (44%)	Gaps:	60/239 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QSTVLTNLQRGNTE--------ATFCPVE-----VSLSFHERAGQGEITEEQVAAERARQQNIDY 95
            |:.::...::||.|        ...|.:|     .:|....:.|...|.||.:..    ..|:::
Mouse    39 QTPLMIAAEQGNVEIVKELIKNGANCNLEDLDNWTALISASKEGHIHIVEELLKC----GANLEH 99

  Fly    96 KDAHGFTALHWAASYGQLVSVQLLVAAGANVN-TMAPDLISPLLLAAAGGHNEIVRFLLEHGAD- 158
            :|..|:|||.||...|:...|:||::.|||.: |.....:.|::.||..||.:||..||::||.
Mouse   100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAGRGHADIVHLLLQNGAKV 164

  Fly   159 ----------------SGHMDIVGN----------------TALMYAAAGNHPHTCNELLAKDLD 191
                            .||::.|.:                |||:.|..|.:..:..|:|.::.:
Mouse   165 NCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPN 229

  Fly   192 LSATNEDGDTAYSLAVEHG-AHLAQALLEQYMTAIITAGAFGSI 234
            ::.|::||:||..:|.:.| ..:.|.||:        ||.:.:|
Mouse   230 VNLTDKDGNTALMIASKEGHIEIVQDLLD--------AGTYVNI 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5846	NP_001303318.1	ANK	94..218	CDD:238125	44/158 (28%)
		ANK repeat	99..130	CDD:293786	14/31 (45%)
		Ank_2	104..196	CDD:289560	32/125 (26%)
		ANK repeat	132..163	CDD:293786	13/47 (28%)
		ANK repeat	165..196	CDD:293786	8/46 (17%)
		Ank_2	170..234	CDD:289560	17/64 (27%)
Kidins220	XP_006515313.1	Ank_4	13..58	CDD:372654	4/18 (22%)
		ANK repeat	38..68	CDD:293786	5/28 (18%)
		PHA02874	49..>378	CDD:165205	60/229 (26%)
		ANK repeat	70..101	CDD:293786	6/34 (18%)
		ANK repeat	103..132	CDD:293786	13/28 (46%)
		ANK repeat	170..198	CDD:293786	3/27 (11%)
		ANK repeat	236..267	CDD:293786	12/38 (32%)
		ANK repeat	269..299	CDD:293786
		ANK repeat	302..332	CDD:293786
		ANK repeat	335..366	CDD:293786
		PHA02736	<349..413	CDD:165103
		KAP_NTPase	441..954	CDD:284995
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0502
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810