DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5846 and Rfxank

DIOPT Version :9

Sequence 1:	NP_001303318.1	Gene:	CG5846 / 34326	FlyBaseID:	FBgn0032171	Length:	234	Species:	Drosophila melanogaster
Sequence 2:	NP_001013154.1	Gene:	Rfxank / 306353	RGDID:	1311390	Length:	284	Species:	Rattus norvegicus

Alignment Length:	231	Identity:	79/231 - (34%)
Similarity:	119/231 - (51%)	Gaps:	17/231 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PANTIQTNANSDDDEGVRSAPTSMLVLDAKRKSAFLPYRPQSTVLTNLQRGNTEATFCPVEV-SL 67
            ||.::.|........|.::.|  :|.      .:||.:   ||.|||.|||| |.:..|..: ||
  Rat    64 PAASVWTPLAQAQTPGEQALP--LLA------GSFLKH---STTLTNRQRGN-EVSALPATLDSL 116

  Fly    68 SFHERAGQGEITEEQVAAERARQQNIDYK-DAHGFTALHWAASYGQLVSVQLLVAAGANVNTMAP 131
            |.|:.|.|||::  |:.....:..|:..| |..|||.|.||:::|::.:|:.|:..||:.:.:|.
  Rat   117 SIHQLAAQGELS--QLKDHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLDWGADPHILAK 179

  Fly   132 DLISPLLLAAAGGHNEIVRFLLEHGADSGHMDIVGNTALMYAAAGNHPHTCNELLAKDLDLSATN 196
            :..|.|.||:.||:.:|||.||:...|....|..|.|.|:||..|||......|||:..||:...
  Rat   180 ERESALSLASMGGYTDIVRLLLDRDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEA 244

  Fly   197 EDGDTAYSLAVEHGAHLAQALLEQYMTAIITAGAFG 232
            :.|.|...|||..|....|.::|.::..:. .|..|
  Rat   245 DSGYTPMDLAVALGYRKVQQVMESHILKLF-QGTLG 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5846	NP_001303318.1	ANK	94..218	CDD:238125	47/124 (38%)
		ANK repeat	99..130	CDD:293786	11/30 (37%)
		Ank_2	104..196	CDD:289560	35/91 (38%)
		ANK repeat	132..163	CDD:293786	12/30 (40%)
		ANK repeat	165..196	CDD:293786	13/30 (43%)
		Ank_2	170..234	CDD:289560	21/63 (33%)
Rfxank	NP_001013154.1	ANKYR	89..271	CDD:223738	71/187 (38%)
		ANK repeat	118..145	CDD:293786	8/28 (29%)
		ANK repeat	147..178	CDD:293786	11/30 (37%)
		Ank_2	152..242	CDD:403870	35/89 (39%)
		ANK repeat	180..211	CDD:293786	12/30 (40%)
		ANK repeat	213..241	CDD:293786	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0502
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2760
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4816
OMA	1	1.010	-	-		QHG47600
OrthoDB	1	1.010	-	-		D1348558at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45498
orthoMCL	1	0.900	-	-		OOG6_112256
Panther	1	1.100	-	-	LDO	PTHR24124
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.840