DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5846 and kidins220

DIOPT Version :9

Sequence 1:	NP_001303318.1	Gene:	CG5846 / 34326	FlyBaseID:	FBgn0032171	Length:	234	Species:	Drosophila melanogaster
Sequence 2:	XP_012818173.1	Gene:	kidins220 / 100145198	XenbaseID:	XB-GENE-5839632	Length:	1764	Species:	Xenopus tropicalis

Alignment Length:	239	Identity:	63/239 - (26%)
Similarity:	110/239 - (46%)	Gaps:	60/239 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QSTVLTNLQRGNTE--------ATFCPVE-----VSLSFHERAGQGEITEEQVAAERARQQNIDY 95
            |:.::...::||.|        ...|.:|     .:|....:.|..||..|.:    :...|:::
Frog    39 QTALMLAAEQGNLEIVQELLRNRANCNLEDVDNWTALISAAKEGHLEIVRELL----SYNANLEH 99

  Fly    96 KDAHGFTALHWAASYGQLVSVQLLVAAGANVN-TMAPDLISPLLLAAAGGHNEIVRFLLEHGAD- 158
            :|..|:|||.||:..|.:..|.||::.|||.| |.....:.|::.||..||::||:.||::||.
Frog   100 RDMGGWTALIWASYKGSIDVVDLLLSKGANPNITGLQYSVYPVIWAAGRGHSDIVKLLLQYGAKV 164

  Fly   159 ----------------SGHMDIV----------------GNTALMYAAAGNHPHTCNELLAKDLD 191
                            .||::.|                ..|||:.|..|.:..|..|:|.::.:
Frog   165 NCSDKFGTTPLIWAARKGHLECVKYLLQMGADVDQEGANSITALIVAVKGGYTDTVKEILKRNPN 229

  Fly   192 LSATNEDGDTAYSLAVEHG-AHLAQALLEQYMTAIITAGAFGSI 234
            ::.|::||:||.::|.:.| ..:.|.||:        ||.:.:|
Frog   230 VNLTDKDGNTALTIAAKEGHTEIVQDLLD--------AGTYVNI 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5846	NP_001303318.1	ANK	94..218	CDD:238125	46/158 (29%)
		ANK repeat	99..130	CDD:293786	15/31 (48%)
		Ank_2	104..196	CDD:289560	34/125 (27%)
		ANK repeat	132..163	CDD:293786	13/47 (28%)
		ANK repeat	165..196	CDD:293786	9/46 (20%)
		Ank_2	170..234	CDD:289560	18/64 (28%)
kidins220	XP_012818173.1	Ank_4	9..58	CDD:290365	4/18 (22%)
		ANK	32..191	CDD:238125	42/155 (27%)
		ANK repeat	37..68	CDD:293786	5/28 (18%)
		Ank_2	42..133	CDD:289560	26/94 (28%)
		ANK repeat	70..101	CDD:293786	6/34 (18%)
		ANK repeat	104..134	CDD:293786	14/29 (48%)
		ANK repeat	137..168	CDD:293786	11/30 (37%)
		Ank_2	143..234	CDD:289560	21/90 (23%)
		ANK	165..290	CDD:238125	24/109 (22%)
		ANK repeat	170..198	CDD:293786	3/27 (11%)
		Ank_2	208..299	CDD:289560	19/66 (29%)
		ANK	231..356	CDD:238125	13/43 (30%)
		ANK repeat	236..267	CDD:293786	12/38 (32%)
		ANK repeat	269..299	CDD:293786
		ANK repeat	302..366	CDD:293786
		Ank_2	307..394	CDD:289560
		KAP_NTPase	441..955	CDD:284995
		SAM_superfamily	1215..1281	CDD:301707
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910