DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4658 and meak7

DIOPT Version :9

Sequence 1:	NP_001285789.1	Gene:	CG4658 / 34325	FlyBaseID:	FBgn0032170	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001038430.2	Gene:	meak7 / 561678	ZFINID:	ZDB-GENE-050419-140	Length:	450	Species:	Danio rerio

Alignment Length:	558	Identity:	116/558 - (20%)
Similarity:	193/558 - (34%)	Gaps:	180/558 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNTSSKGESDASEPPLEGGKPYKQHQQHKSSDASHNGVSDVGGSHNNLKVTQAQGSMTRSASGA 65
            |||    |:|..::..|...:|.::.....:.|..|.                     .||::.|
Zfish     1 MGN----GDSVVAQKRLARFRPDERPAVEGTFDRLHG---------------------ARSSASA 40

  Fly    66 DVTEKYLTQLVPVEKLAEILREQTSSKLGINGIVADVFVSQVFPQYADLGQRLFNLMHSNSKATT 130
            ..|.|.|:        .::| :.|..|:....::                :|:|..:||......
Zfish    41 GKTSKGLS--------LDML-QLTMGKMASESMI----------------KRVFQGLHSIDPGVP 80

  Fly   131 KHLGAVAFRQQCERFLGIMDDSKTLECYIKMYAQEENPDQIDKTGVTRLLHICYTIAMQHSGNAV 195
            .|.|....|:|...||..:         ::..|:|..|               ..:||.....|.
Zfish    81 LHPGDGVSREQLLIFLADV---------LRGTAEERAP---------------LVLAMAEGAKAT 121

  Fly   196 LCPAINRTFGSVTKSIFLCHDSMSLGYVCRWFEQNLMRLVL--LVHKYCVHTLSTAYRGLEQQNQ 258
            :         :.|:.|             |.|.::|:...:  |.||..:.    |::.....:.
Zfish   122 V---------TTTEQI-------------RGFMEDLVYAAVQTLAHKGHLR----AWQPERMGDG 160

  Fly   259 SCGIELQTPVLEQRNPFTDTTDFSGGSTREMDSL------MPLSQAWL-------LAGALPPLYS 310
            :.|::|   :.||   .|.....|..:|.::..|      :|:...:|       |...||.  .
Zfish   161 AQGVKL---LAEQ---LTSELKPSDQNTCDIACLEDWLFRIPMMAMFLELLIGEGLGVVLPS--R 217

  Fly   311 KPQTVTPP---ATKGNNNVSASTAVQIFKDKLSMMP----SHWTLLYNSNEHGVGANRFLHHVLG 368
            .|.|:.||   |...:.....|..:.:|...|  :|    :.|.:|:::..||....|.|.....
Zfish   218 PPPTLLPPCQFAPWTDLRCVLSLPLLMFLSPL--LPEGHSAPWRMLFSTKMHGESFTRLLGSCKS 280

  Fly   369 YRGPTLVLLHTKDEQTYC---VASPSEWKETHLFVGGEGSCVIQLLP---KFVILEKKPNILYLN 427
             ||||::|:  ||.:.:.   .||.| |:....|.|.....:..:.|   .|.......:.:|||
Zfish   281 -RGPTVLLV--KDTKGHIFGGFASQS-WEVKPQFQGDSRCFLFSVFPYMRVFTCTGYNDHYMYLN 341

  Fly   428 TSIRGYPKGLRAG--------------------ADPR-----KPIIAVDEHFENIDCKGLAAGLM 467
            ...:..|.||..|                    |.||     .|.::.||.|:          |.
Zfish   342 QGQQTMPNGLGMGGQHGYFGLWLDYDFGHGHSRARPRCTTYGSPQLSADEDFK----------LD 396

  Fly   468 SIEVWGCGDKSSREVQLDIKKWQIKEA--ERQRTVKLT 503
            ::||||.| |...|.:.|.||..|.:|  |.|..:::|
Zfish   397 TLEVWGVG-KLPEEQEEDEKKKSILDADLEVQAMMEMT 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4658	NP_001285789.1	TLDc	327..475	CDD:214733	44/182 (24%)
meak7	NP_001038430.2	TLDc	237..404	CDD:214733	44/182 (24%)
meak7	NP_001038430.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..450		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D585082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920