DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4709 and Lime1

DIOPT Version :9

Sequence 1:	NP_001285788.1	Gene:	CG4709 / 34324	FlyBaseID:	FBgn0032169	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_076173.1	Gene:	Lime1 / 72699	MGIID:	1919949	Length:	269	Species:	Mus musculus

Alignment Length:	112	Identity:	26/112 - (23%)
Similarity:	44/112 - (39%)	Gaps:	23/112 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 LGPG---------ESTQQG-EQVTKKAKTNELQQHSTKTLNVETVRIADEIRRKQRDMAKVKQSL 463
            ||||         :.|:|| :::.:|||.....|     ::|...|:.   :.|:||...|...|
Mouse   169 LGPGAEYACIQKHKGTEQGCQELQQKAKVIPATQ-----MDVLYSRVC---KPKRRDPRPVTDQL 225

  Fly   464 DRNSGDAQLQKRLQVQMQSHKQELATLQAQERSLSKEQQTRKSKNKM 510
            :...|...|.....|:     .|...|:.|:......:...:|..:|
Mouse   226 NLQDGRTSLPLGSDVE-----YEAINLRGQDMKQGPLENVYESIKEM 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4709	NP_001285788.1	ZnF_C3H1	155..176	CDD:214632
CG4709	NP_001285788.1	G-patch	312..355	CDD:279867
Lime1	NP_076173.1	LIME1	27..266	CDD:291977	25/109 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..134
		Interaction with GRB2	137..140
		Interaction with CSK. /evidence=ECO:0000250	175..178		0/2 (0%)
		Interaction with CSK. /evidence=ECO:0000250	207..210		0/2 (0%)
		Interaction with LCK and PIK3R1. /evidence=ECO:0000269\|PubMed:14610044	242..245		1/2 (50%)
		Interaction with LCK, PLCG2 and PIK3R1. /evidence=ECO:0000269\|PubMed:14610044, ECO:0000269\|PubMed:16249387	261..264		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838847
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6961
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.880