DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4709 and zgpat

DIOPT Version :9

Sequence 1:	NP_001285788.1	Gene:	CG4709 / 34324	FlyBaseID:	FBgn0032169	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_956779.1	Gene:	zgpat / 393457	ZFINID:	ZDB-GENE-040426-1248	Length:	504	Species:	Danio rerio

Alignment Length:	570	Identity:	174/570 - (30%)
Similarity:	261/570 - (45%)	Gaps:	128/570 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEE----YEAQLLVVEQALENAADDAQRQDLLALKNNLQELLALTRES------------GDEAP 49
            :||    |.|||..||.||......|::.|||.||.:||:|:.||..|            .:||.
Zfish     6 LEEAIGTYRAQLQQVELALSAGLGSAEQDDLLKLKEDLQQLIELTESSLVSVKKSQLLAALEEAS 70

  Fly    50 IDE----LPQQGDNLDDELQRLKSELND--LEAAGSSQTALDEERQLADLRTKYTAMVGEKCSAP 108
            .::    :||: ..||:|.....:||::  .|...:..|..:.|.:..|:.       |.|..||
Zfish    71 TNQSDTSVPQE-TALDNEFAAFYAELSEDSNEVKPNPDTDEENEEEEQDIS-------GTKVCAP 127

  Fly   109 HEHSWGTC-YHNALICGVDDEVVMNSEGVLDARLRVLFTNPTHREMLPCSYYLEGECRFDEAKCR 172
            :..||||. ||||::...::     .||. :||:||.:.:|||:.|.||.:||||:|||.: .||
Zfish   128 YRTSWGTLEYHNAMVVCPEE-----PEGE-EARVRVFYIHPTHKSMKPCGFYLEGKCRFMD-NCR 185

  Fly   173 FSHGALVTGSSIRKYNPPDFHKLSRSRPVFALLPDRLWHRGRVLCVNFVEQICRVRLDGQDHKER 237
            :|||.:|..|.:|.:...|...:.......|...|.:|:..|:                   .|.
Zfish   186 YSHGEVVCVSELRDFLEADISNMESGSACLAKHEDGIWYPARI-------------------SEI 231

  Fly   238 ERDF---KFEELYPLTTDQDED---DELSSEESNSSMNDNSSDEAESD----------MDDLEEA 286
            |..|   ||:.|.......:.|   ..|..::.:||.:.:|.|:||.|          .:||.:.
Zfish   232 EGGFYTVKFDSLLLKEAVLEADGIIPPLRQDDVSSSSSSDSEDDAECDGGYAKVFTSREEDLAQV 296

  Fly   287 RRARMVELSLFTFKPTERLGAWEEFTRGIGSKLMEKMGYIHGTGLGSDGRGIVTPVSAQILPQGR 351
            ..|...              .||..||||||||:.||||..|.|||....|.|.||.|.:||:|.
Zfish   297 NTAEFC--------------GWEAHTRGIGSKLLMKMGYELGKGLGKTLSGRVEPVQAVVLPKGH 347

  Fly   352 SLDACMELRE----AANGDKDYFSVERKLKRAQRRQRKADEKAYVRESQRVDVFTFLN------- 405
            |||.|.||.:    ||....:..|.:||.|:     :||.      .|.|.:||.|||
Zfish   348 SLDICAELTQRKTAAAIAKNNPTSHKRKAKK-----KKAS------TSTRHNVFDFLNSKLGDRA 401

  Fly   406 ------DSVLGPGESTQQGEQVTKKAKTNELQQHSTKTLNVETVRIADEIRRKQRDMAKVKQSLD 464
                  .|.|..|....:|.:.||            ::|||.....|:::.:.:|::.::.:||.
Zfish   402 QSASHSSSSLVTGAEAYRGGKSTK------------RSLNVRLFEAAEKVTQVEREIQQLTKSLS 454

  Fly   465 -RNSGDAQLQKRLQVQMQSHKQELATLQAQERSLSKEQQTRKSKNKMFEF 513
             ||..||.:..||:.::.:.::.|..|:|||:::.:||:...:..||.||
Zfish   455 KRNGRDAAVVSRLEEKLAASRKLLEQLKAQEQAIQREQKKADTHKKMTEF 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4709	NP_001285788.1	ZnF_C3H1	155..176	CDD:214632	12/20 (60%)
CG4709	NP_001285788.1	G-patch	312..355	CDD:279867	26/42 (62%)
zgpat	NP_956779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..121		5/32 (16%)
		ZnF_C3H1	167..190	CDD:214632	14/23 (61%)
		TUDOR	211..>241	CDD:119391	8/48 (17%)
		G-patch	308..351	CDD:279867	26/42 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582678
Domainoid	1	1.000	109	1.000	Domainoid score	I6333
eggNOG	1	0.900	-	-		E1_KOG2185
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41874
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3742
OMA	1	1.010	-	-		QHG59932
OrthoDB	1	1.010	-	-		D1238995at2759
OrthoFinder	1	1.000	-	-		FOG0004918
OrthoInspector	1	1.000	-	-		oto41349
orthoMCL	1	0.900	-	-		OOG6_106211
Panther	1	1.100	-	-	LDO	PTHR46297
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3700
SonicParanoid	1	1.000	-	-		X4586
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800