DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4709 and Zgpat

DIOPT Version :9

Sequence 1:	NP_001285788.1	Gene:	CG4709 / 34324	FlyBaseID:	FBgn0032169	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001009656.1	Gene:	Zgpat / 296478	RGDID:	1310801	Length:	507	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	169/551 - (30%)
Similarity:	268/551 - (48%)	Gaps:	91/551 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEEYEAQLLVVEQALENAADDAQRQDLLALKNNLQELLALT-------RESGDEAPIDELPQQGD 58
            ::.|.|||..||.||....|.:::.||..|:.:|:||:.||       |:|...:.:|:..|:
  Rat    10 LQTYRAQLQQVELALGAGLDASEQADLRQLQGDLKELIELTEASLLSVRKSKLLSTVDQEHQE-- 72

  Fly    59 NLDDE---LQRLKSELNDLEAAGSSQT-------------ALDEERQLADLRTKYTAMVGEKCSA 107
              |.|   .|:..:|...::....|:|             ||:||.:..||..    :.|.|.:|
  Rat    73 --DAEYLAFQKAIAEEAPVDPGNDSKTVPGSEVQPTPTSSALEEEEEDPDLED----LSGAKVNA 131

  Fly   108 PHEHSWGTC-YHNALICGVDDEVVMNSEGVLDARLRVLFTNPTHREMLPCSYYLEGECRFDEAKC 171
            |:..:|||. ||||::.|.::.    .:|  .|.:|||:..|||:.:.||.::|||:|||.| .|
  Rat   132 PYYSAWGTLEYHNAMVVGAEEA----EDG--SACVRVLYLYPTHKSLKPCPFFLEGKCRFKE-NC 189

  Fly   172 RFSHGALVTGSSIRKYNPPDFHKLSRSRPVFALLPDRLWHRGRVLCVNFVEQICRVRLDGQDHKE 236
            |||||.||:...:|.:..||...|.......|...|.|||..|:..|:  .....|:.|....||
  Rat   190 RFSHGQLVSVDELRPFQDPDLSLLQTGSACLAKHQDGLWHPARITDVD--NGYYTVKFDSLLLKE 252

  Fly   237 R--ERDFKFEELYPLTTDQDEDDELSSEESNSSMNDNSSDEAESDMDDLEEARRARMVEL-SLFT 298
            .  |.|   ..|.||.|:                   ::|.::||..|..::..||:||. ::.|
  Rat   253 AVVEGD---SILPPLRTE-------------------ATDSSDSDTGDASDSSYARVVEANTVDT 295

  Fly   299 FKPTERLGAWEEFTRGIGSKLMEKMGYIHGTGLGSDGRGIVTPVSAQILPQGRSLDACMELREAA 363
            ...:.....||..||||||||:.||||..|.|||....|.|.|:.|.:||:|:|||.|.|:
  Rat   296 GTCSSAFAGWEVHTRGIGSKLLVKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSLDQCAEI---- 356

  Fly   364 NGDKDYFSVERKLKRAQR------RQRKADEKAYVRESQRVDVFTFLNDSVLGPGESTQQGEQVT 422
                    :::|.|:.|.      |.|:...:...|...| :||.|||:.:......|......|
  Rat   357 --------LQKKTKQGQTGASRPPRCRRRSSRPEGRPPPR-NVFDFLNEKLQSQVPGTPDAGVDT 412

  Fly   423 KKAKTNELQQHSTKT----LNVETVRIADEIRRKQRDMAKVKQSLDRNSG-DAQLQKRLQVQMQS 482
            .:.:..:: .|::|:    |:::..:..::|.|.|||:..::::|.||:| .......||.:::.
  Rat   413 PERRNKDM-YHASKSAKQALSLQLFQTEEKIERTQRDIRGIQEALTRNTGRHGMATAHLQEKLEG 476

  Fly   483 HKQELATLQAQERSLSKEQQTRKSKNKMFEF 513
            .:::|..|:|||..|.::|:...:..||.||
  Rat   477 AQRQLGQLRAQEADLQRKQRKADTHRKMTEF 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4709	NP_001285788.1	ZnF_C3H1	155..176	CDD:214632	13/20 (65%)
CG4709	NP_001285788.1	G-patch	312..355	CDD:279867	25/42 (60%)
Zgpat	NP_001009656.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	88..125		8/40 (20%)
		ZnF_C3H1	173..194	CDD:214632	13/21 (62%)
		TUDOR	216..262	CDD:119391	13/50 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..283		6/37 (16%)
		G-patch	309..350	CDD:279867	23/40 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..389		7/30 (23%)
		RILP-like	388..>503	CDD:304877	29/116 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..507		7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342656
Domainoid	1	1.000	53	1.000	Domainoid score	I11127
eggNOG	1	0.900	-	-		E1_KOG2185
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41874
Inparanoid	1	1.050	207	1.000	Inparanoid score	I3623
OMA	1	1.010	-	-		QHG59932
OrthoDB	1	1.010	-	-		D1238995at2759
OrthoFinder	1	1.000	-	-		FOG0004918
OrthoInspector	1	1.000	-	-		oto97891
orthoMCL	1	0.900	-	-		OOG6_106211
Panther	1	1.100	-	-	LDO	PTHR46297
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4586
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810