DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4709 and Tfip11

DIOPT Version :9

Sequence 1:	NP_001285788.1	Gene:	CG4709 / 34324	FlyBaseID:	FBgn0032169	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001008292.1	Gene:	Tfip11 / 288718	RGDID:	1311449	Length:	837	Species:	Rattus norvegicus

Alignment Length:	342	Identity:	77/342 - (22%)
Similarity:	135/342 - (39%)	Gaps:	99/342 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 HKERERDFKFEELYPLTTDQDEDDELSS-------------EESNSSMNDNSSDEAESDMDDLEE 285
            :::|....|.|..|.:..::|.|:|..|             ...::.:...:::||:|:..|.||
  Rat    38 NRQRHWQTKEEATYGVWAERDSDEERPSFGGKRARDYSAPVNFISAGLKKGAAEEADSEDSDAEE 102

  Fly   286 ARRARMVELSLF-------------TFKPTER-----------LGAWEEFTRGIGSKLMEKMGYI 326
                :.|:...|             .|||:::           .|:||..|:|||.||::||||:
  Rat   103 ----KPVKQEDFPKDLGPKKLKTGGNFKPSQKGFAGGTKSFMDFGSWERHTKGIGQKLLQKMGYV 163

  Fly   327 HGTGLGSDGRGIVTPVSAQILPQGRSLDACMELREAANGDKDYFSVERKLKRAQ-----RRQRKA 386
            .|.|||.:.:||:.|:.|:              :....|....:..||..:..|     ..:.:|
  Rat   164 PGRGLGKNAQGIINPIEAK--------------QRKGKGAVGAYGSERTTQSLQDFPVADSEEEA 214

  Fly   387 DEKAYVRESQ-RVDVFTFLNDSVLGPGESTQQGEQVTKKAKTNELQQHSTKTLNVETVRIADEIR 450
            :|:.....|| |.|.    :.|...|..|.:..|::..|.:.::......|.|:  .|::.|...
  Rat   215 EEEFQKELSQWRKDP----SGSKKKPKYSYKTVEELKAKGRVSKKLTAPQKELS--QVKVIDMTG 273

  Fly   451 RKQRDMAKVKQSLDRNS-----------------------GDA--QLQKRLQVQMQSHKQELATL 490
            |:|:......|...::|                       |.|  :|:..||:.::..:||:...
  Rat   274 REQKVYYSYSQISHKHSVPDEGVPLLAQLPPTAGKEAKVPGFALPELEHNLQLLIERTEQEIIQS 338

  Fly   491 QAQ---ER----SLSKE 500
            ..|   ||    |||.|
  Rat   339 DRQLQYERDMVVSLSHE 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4709	NP_001285788.1	ZnF_C3H1	155..176	CDD:214632
CG4709	NP_001285788.1	G-patch	312..355	CDD:279867	18/42 (43%)
Tfip11	NP_001008292.1	Required for interaction with DHX15. /evidence=ECO:0000250	1..50		3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		TIP_N	18..104	CDD:289242	14/69 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..73		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..135		11/53 (21%)
		G-patch	149..193	CDD:279867	19/57 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..236		11/56 (20%)
		GCFC	397..666	CDD:285127
		Nuclear localization signal. /evidence=ECO:0000250	700..705
		Required for nuclear speckle localization. /evidence=ECO:0000250	710..734
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1238995at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010