DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4709 and zgpa-1

DIOPT Version :9

Sequence 1:	NP_001285788.1	Gene:	CG4709 / 34324	FlyBaseID:	FBgn0032169	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_501296.1	Gene:	zgpa-1 / 177568	WormBaseID:	WBGene00016383	Length:	432	Species:	Caenorhabditis elegans

Alignment Length:	517	Identity:	115/517 - (22%)
Similarity:	217/517 - (41%)	Gaps:	99/517 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEEYEAQLLVVEQALENAADDAQRQDLLALKNNLQELLAL-------TRESGDEAPIDELPQQGD 58
            :|..:.|:..:::.:....::..|.:....|.:|:||::|       |::|.|:..|||..:...
Worm     4 LENLKDQIKRIDEMIVQETNEETRVEYEQTKMDLEELVSLMEEDEEKTQKSPDDDEIDEQDEDSA 68

  Fly    59 NLDDELQRLKSELNDLEAAGSSQTALDEERQLADLRTKYTAMVGEKCSAPHEHSWGTCYHNALIC 123
            .:||                                |...:::|.:|..|::.......|.|:|.
Worm    69 EIDD--------------------------------TSTDSLLGSRCMVPYDSDRSLSLHTAIIM 101

  Fly   124 GVDDEVVMNSEGVLDARLRVLFTNPTHREMLPCSYYLEGECRFDEAKCRFSHGALVTGSSIRKYN 188
            .::.          ..|:||||::||...|.||:::|...|:|:| .||||||..|....|:.|.
Worm   102 EIES----------SKRVRVLFSHPTCSAMKPCTHFLSSSCKFNE-NCRFSHGYSVELERIQDYQ 155

  Fly   189 PPDFHKLSRSRPVFALLPDRLWHRGRVLCVNFVEQICRVRLDGQDHKERERDFKFEELYPLTTDQ 253
            .||:..:.....|.......:|..||:..::......:|...|.:...:.:|     |.|:
Worm   156 VPDYSFIVEEGLVLVKGMSDIWELGRISAIDTQNVAVKVLKSGIEISSKRKD-----LVPI---- 211

  Fly   254 DEDDELSSEESNSSMNDNSSDEAESDMDDLEEARRARMVELSLFTFKPTERLGAWEEFTRGIGSK 318
            .|.:|.:.:|.:|              :..:|.::..:..:::      ..||.|.  ..|:|.|
Worm   212 GEVEEPTKQEQSS--------------ESWKELKQETLGNVTV------GDLGKWN--GGGVGMK 254

  Fly   319 LMEKMGYIHGTGLGSDGRGIVTPVSAQILPQGRSLDACMELREAANGDKDYFSVERK-LKRAQRR 382
            ||.||||..|.|||....|||..:.|:|..:..|||..|             :.:|| :.|.:.:
Worm   255 LMMKMGYKVGEGLGKRSDGIVHAIQARICKKNASLDEVM-------------TRKRKFIDRKEVQ 306

  Fly   383 QRKADEKAYVRESQRVDVFTFLNDSVLGPGESTQQGEQVTKKAKTNELQQHSTKTLNVETVRIAD 447
            :.|..:|....:...:|:|.|:|..:    |...:......:.:|.|:..:|:|||..:.:.:..
Worm   307 KNKNIKKLKTTDESEMDIFAFINRKL----EKKNERTFADVRKETQEMAGYSSKTLGAKNLDLEL 367

  Fly   448 EIRRKQRDMAKVKQSLDRNSGDAQLQKRLQVQMQSHKQELATLQAQERSLSKEQQTRKSKNK 509
            |:::.:....|:|..:.||.||.....::...::....::.::..:...:..|..:|.||.|
Worm   368 ELKQLKEKQNKLKSGIQRNRGDKNTVSKMSESLREVDAKIESINRKLNRIQSEVSSRNSKRK 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4709	NP_001285788.1	ZnF_C3H1	155..176	CDD:214632	10/20 (50%)
CG4709	NP_001285788.1	G-patch	312..355	CDD:279867	20/42 (48%)
zgpa-1	NP_501296.1	ZnF_C3H1	121..144	CDD:214632	12/23 (52%)
		G-patch	249..289	CDD:279867	18/39 (46%)
		NAT_SF	<254..>421	CDD:302625	43/183 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159228
Domainoid	1	1.000	80	1.000	Domainoid score	I5581
eggNOG	1	0.900	-	-		E1_KOG2185
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41874
Inparanoid	1	1.050	137	1.000	Inparanoid score	I3120
Isobase	1	0.950	-	0	Normalized mean entropy	S6961
OMA	1	1.010	-	-		QHG59932
OrthoDB	1	1.010	-	-		D1238995at2759
OrthoFinder	1	1.000	-	-		FOG0004918
OrthoInspector	1	1.000	-	-		oto18636
orthoMCL	1	0.900	-	-		OOG6_106211
Panther	1	1.100	-	-	LDO	PTHR46297
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3700
SonicParanoid	1	1.000	-	-		X4586
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790