DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and ABCG1

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	XP_024307909.1	Gene:	ABCG1 / 9619	HGNCID:	73	Length:	786	Species:	Homo sapiens

Alignment Length:	594	Identity:	263/594 - (44%)
Similarity:	369/594 - (62%)	Gaps:	36/594 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 GSKEILHNVCGKFPGSQLIAIMGPSGAGKSTLLDALSGFKTTGVDGSILLNGRRRDLPSFRRMSC 185
            |.|.:|..:.|||...:|:|||||||||||||::.|:|::.||:.|::|:||..|||..||::||
Human   204 GYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSC 268

  Fly   186 YITQDDRLQPLLTVNENMHIAADLKLGQTVSYEEKESR---IEDILLLLGLYNHDQTLTMRLSGG 247
            ||.|||.|.|.|||.|.|.::|.|||     .|:.|.|   :::||..|||.:...|.|..||||
Human   269 YIMQDDMLLPHLTVQEAMMVSAHLKL-----QEKDEGRREMVKEILTALGLLSCANTRTGSLSGG 328

  Fly   248 QKKRLSIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTAKLFQIFD 312
            |:|||:||:||:|||.|||.||||:||||:||.:|:.|:|.|...||:||||||||:||||::||
Human   329 QRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFD 393

  Fly   313 QVYVLSAGNCVYQGSTQKLVPFLQSVDLPCPMYHNPADYIIELACGEYGYDKVDTLKLATENGSC 377
            |:||||.|.|||:|....|||:|:.:.|.||.||||||:::|:|.|||| |:...|..|...|.|
Human   394 QLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYG-DQNSRLVRAVREGMC 457

  Fly   378 ----------------LTWFHNPSAVLRAEVLMRKYPIPKKTKSRSLEDT-SYSNQC----SVLL 421
                            ..| |.||    .||...|.....:..|.|:|.. |:|..|    .:|.
Human   458 DSDHKRDLGGDAEVNPFLW-HRPS----EEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILF 517

  Fly   422 RRGFIKAKRDTTMTHLRIGVNIAVAALFGAMYDHTGREGSRVLDNYNLLFAILMHHSMTTMMLTV 486
            :|.|:...||:.:|||||..:|.:..|.|.:|...|.|..:||.|...||..::......:|.||
Human   518 KRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTV 582

  Fly   487 LTFPMDISILIKEHFNRWYSLKAYYTAMTLVDLPISIISCFFFTVIVYLWSYQPMEWIRFFMFFS 551
            ||||:::.:.::||.|.||||||||.|.|:.|:|..|:....:..|||..:.||.:.:||.:|.:
Human   583 LTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAA 647

  Fly   552 ISLLTVFVGHSFGLMIGAWFDVVN-GTFLAPVLTIPMMMFAGFGVTLRDLPSYLRWGSHISYLRY 615
            :..:|..|..|.||:|||....:. .||:.||..||:::|:||.|:...:|:||:|.|:|||:||
Human   648 LGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRY 712

  Fly   616 GLEGFISAIYGLDRGTLACEEAPYCHYRYPKKFLEEITMRGDQFWNDVIALGVMILVFRFVSYVV 680
            |.||.|.:||||||..|.|:....||::..:..|.|:.:...:.:.|.|.||:..:..|.::|.|
Human   713 GFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFV 777

  Fly   681 LKAKIKSIR 689
            |:.||::.|
Human   778 LRYKIRAER 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	262/592 (44%)
		ABCG_EPDR	102..326	CDD:213180	118/207 (57%)
		ABC2_membrane	420..623	CDD:279410	84/203 (41%)
ABCG1	XP_024307909.1	3a01204	202..786	CDD:273361	262/592 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11212
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2712
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm41963
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760