DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and PDR18

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_014468.3	Gene:	PDR18 / 855807	SGDID:	S000005353	Length:	1333	Species:	Saccharomyces cerevisiae

Alignment Length:	751	Identity:	182/751 - (24%)
Similarity:	306/751 - (40%)	Gaps:	184/751 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IGEVTSSRVYNSTTVPVGNSG-------GWRNA-QSSVTP--------PPIPTPPQVNYTNGNEP 73
            ||.:....|:.....||.:.|       |.:|| |.|.:.        ..|.|.......:.|:.
Yeast   650 IGYIVLRAVFTEYKSPVKSGGDALVVKKGTKNAIQRSWSSKNDEENLNASIATQDMKEIASSNDD 714

  Fly    74 SKQPPLEPVVEEEVHFDTDALNNLPAREPVDMEFKELSLTVKLGFNRGSKEILHNVCGKFPGSQL 138
            |.....|.:....|..                 :|.:|.|:.  .:.|.:::|.:|.|......|
Yeast   715 STSADFEGLESTGVFI-----------------WKNVSFTIP--HSSGQRKLLDSVSGYCVPGTL 760

  Fly   139 IAIMGPSGAGKSTLLDALSGFKTTGVDGSILLNGRRRDLPSFRRMSCYITQDDRLQPLLTVNENM 203
            .|::|.|||||:|||:.|:......:.|.:|::|...| .||:|.:.|:.|.|.....|||.|::
Yeast   761 TALIGESGAGKTTLLNTLAQRNVGTITGDMLVDGLPMD-ASFKRRTGYVQQQDLHVAELTVKESL 824

  Fly   204 HIAADLKLGQTVSYEEKESRIEDILLLLGLYNHDQTLTMRLSGG----QKKRLSIAMELINNP-T 263
            ..:|.::..|::...||...:|.|:.:|.:....:.|...:..|    |:|:|||.:||:..| .
Yeast   825 QFSARMRRPQSIPDAEKMEYVEKIISILEMQEFSEALVGEIGYGLNVEQRKKLSIGVELVGKPDL 889

  Fly   264 VMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTAKLFQIFDQVYVL-SAGNCVYQG- 326
            ::||||||:||||.|...|:::||:|...|::|:||||||:|.||:.||::.:| ..|..:|.|
Yeast   890 LLFLDEPTSGLDSQSAWAVVKMLKRLALAGQSILCTIHQPSATLFEQFDRLLLLGKGGQTIYFGE 954

  Fly   327 ----STQKLVPFLQSVDLPCPMYHNPADYIIE-LACG-----------------EYG--YDKV-D 366
                |:..:..|.::....|....|||:||:| :..|                 ||.  .:|: |
Yeast   955 IGKNSSSVIKYFEKNGARKCQQNENPAEYILEAIGAGATASVQQNWPDIWQKSHEYANINEKIND 1019

  Fly   367 TLKLATENGSCLTWFHNPSAVLRAEVLMRKYPIPKKTKSR-SLEDTSYSNQCSVLLRRGFIKAKR 430
            .:|..:.     |..|                   ||.:| |...||||.|...:|:|..:...|
Yeast  1020 MIKDLSS-----TTLH-------------------KTATRASKYATSYSYQFHHVLKRSSLTFWR 1060

  Fly   431 DTTMTHLRIGVNIAVAALF-GAMYDHTGREGSRVLDNYNLLFAILMHHSMTTMMLTVLTFP---- 490
            :......:: :.:.::.|| |..:.|.   |...:...|.|||        ..|..|::.|
Yeast  1061 NLNYIMAKM-MLLMISGLFIGFTFFHV---GVNAIGLQNSLFA--------CFMAIVISAPATNQ 1113

  Fly   491 -MDISILIKEHFN-RWYSLKAYYTAMTLV-----DLPISIISCFFFTVIVYLWSYQPM----EWI 544
             .:.:.:.||.:. |......::.::.|:     :||..::    |:.|.::.||.|:    |..
Yeast  1114 IQERATVAKELYEVRESKSNMFHWSLLLITHYLNELPYHLL----FSTIFFVSSYFPLGVFTEAS 1174

  Fly   545 R---FFMFFSISLLTVFVGHSFGLMI--------GAWFDVVNGTFLAPVLTI-----PMMMFAGF 593
            |   |::.::|.....::|  ..|||        .|  :|:.|..|:.:|:.     |..:..||
Yeast  1175 RSSVFYLNYAILFQLYYIG--LALMILYMSPNLQSA--NVIVGFILSFLLSFCGAVQPASLMPGF 1235

  Fly   594 GVTLRDLPSYLRWGSHISYLRYGLEG----------------------------FISAIYGLDRG 630
            ...:..|..|       :|....|.|                            |....:....|
Yeast  1236 WTFMWKLSPY-------TYFLQNLVGLLMHDKPVRCSKKELSLFNPPVGQTCGEFTKPFFEFGTG 1293

  Fly   631 TLACEEA----PYCHYRYPKKFLEEITMRGDQFWND 662
            .:|..:|    .||.|:...::|..|.......|.:
Yeast  1294 YIANPDATADCAYCQYKVGDEYLARINASFSYLWRN 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	165/663 (25%)
		ABCG_EPDR	102..326	CDD:213180	81/229 (35%)
		ABC2_membrane	420..623	CDD:279410	48/262 (18%)
PDR18	NP_014468.3	3a01205	1..1333	CDD:273362	182/751 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2712
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	5	4.980