DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and AUS1

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_014654.1	Gene:	AUS1 / 854175	SGDID:	S000005537	Length:	1394	Species:	Saccharomyces cerevisiae

Alignment Length:	715	Identity:	175/715 - (24%)
Similarity:	293/715 - (40%)	Gaps:	143/715 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SSRVYNSTTVPVGNSGGWRNAQSSVTPPPIPTPPQVNYTNGNEPSKQPPLEPVVEEEVHFDTDAL 94
            ||...:|..|.:..|....::.||::..|....|.......|:.::||..| .||.:.|.
Yeast   692 SSARNDSKYVGIPKSHSVSSSSSSLSAVPYQISPSNKEMALNDYNEQPITE-TVETQKHI----- 750

  Fly    95 NNLPAREPVDMEFKELSLTVKLGFNRGSKEILHNVCGKFPGSQLIAIMGPSGAGKSTLLDALSGF 159
                      :.:|.::.||      |:|::::|..| |..|.|.|:||.|||||:|||:.||..
Yeast   751 ----------ISWKNINYTV------GTKKLINNASG-FISSGLTALMGESGAGKTTLLNVLSQR 798

  Fly   160 KTTG-VDGSILLNGR-RRDLPSFRRMSCYITQDDRLQPLLTVNENMHIAADLKLGQTVSYEEKES 222
            ..|| |.|.||::|. ..|..:|:|...::.|.|....||:|.|::.|:..|:.....:|.:..|
Yeast   799 VETGVVSGEILIDGHPLTDEDAFKRSIGFVQQQDLHLDLLSVKESLEISCLLRGDGDRAYLDTVS 863

  Fly   223 RI----EDILLLLGLYNHDQTLTMRLSGGQKKRLSIAMELINNPT-VMFLDEPTTGLDSSSCTKV 282
            .:    .|||:            ..|:..|:|.|||.:||:..|: ::||||||:|||:.:...:
Yeast   864 NLLKLPSDILV------------ADLNPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAALTI 916

  Fly   283 LELLKKLTSQGRTIICTIHQPTAKLFQIFDQVYVLS-AGNCVYQGSTQKLVPFLQSVD--LPCPM 344
            ::.||:|:.||:.|.||||||:..:...||.:::|. .|.||:.|.......:..|.|  |....
Yeast   917 VKFLKQLSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGECVFFGPMDDACGYFMSHDNTLVYDK 981

  Fly   345 YH-NPADYIIELACGEYGYDKVDTLKLA-TENGSCLTWFHNPSAVLRAEVLMRKYPIPKKTKSRS 407
            .| ||||::|:...........||.:.| |.|...:.|    ||:..:.|   :..:.||..:|
Yeast   982 EHDNPADFVIDAVGNSNSSAGKDTAEEALTLNKEAIDW----SALWESSV---EKKLVKKETAR- 1038

  Fly   408 LED----------------TSYSNQCSVLLRRGFIKAKRDTTMTHLRIGVNIAVAALFGAMYDHT 456
            |||                .||..|.:::.||.:|..|||.|....:..:|.......|..:.|.
Yeast  1039 LEDDARASGVDYTTSLWKQPSYLQQLALITRRQYICTKRDMTYVMAKYCLNGGAGLFIGFSFWHI 1103

  Fly   457 GREGSRVLDNYNLLFAILMHHSMTTMMLTVLTFPMDISILIKEHF------NRWYSLKAYYTAMT 515
            ..   .::...:.:|...|...:::.::..:   .|.::..||.:      :..|.......:.:
Yeast  1104 KH---NIIGLQDSIFFCFMALCVSSPLINQI---QDKALKTKEVYVAREARSNTYHWTVLLLSQS 1162

  Fly   516 LVDLPISII-SCFFFTVIVYLWSYQPMEWIRFFMFFSISLLTVFVGHSFGLMIGAWFDVVNGTFL 579
            :::||:::. |..||....:...:....|.....|.:..|...:..     .:|.|.     .:.
Yeast  1163 IIELPLALTSSTLFFVCAFFSCGFNNAGWSAGVFFLNYMLFAAYYS-----TLGLWL-----IYT 1217

  Fly   580 APVLTIPMMM----------FAGFGVTLRDLPSYLRWGSHISYLRYGLEGFISAIYGLDRGTLAC 634
            ||.|....:.          |.|........|::.::...:|...|.:|.|:|.:  |....:.|
Yeast  1218 APNLQTAAVFVAFIYSFTASFCGVMQPYSLFPTFWKFMYRVSPYTYFVETFVSIL--LHNWEIKC 1280

  Fly   635 E-------------------EA------------------PYCHYRYPKKFLEEITMRGDQFWND 662
            :                   ||                  .||.|.....||:...|..|..|.:
Yeast  1281 DMSEMVPGQPLTGQSCGQFMEAFIEEYGGYLHNKNTFTVCAYCTYTVGDDFLKNENMSYDHVWRN 1345

Fly 663 662
Yeast 1346 1345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	159/648 (25%)
		ABCG_EPDR	102..326	CDD:213180	82/231 (35%)
		ABC2_membrane	420..623	CDD:279410	36/219 (16%)
AUS1	NP_014654.1	3a01205	56..1369	CDD:273362	175/715 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	3	3.000