DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and SNQ2

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_010294.1	Gene:	SNQ2 / 851574	SGDID:	S000002418	Length:	1501	Species:	Saccharomyces cerevisiae

Alignment Length:	725	Identity:	189/725 - (26%)
Similarity:	308/725 - (42%)	Gaps:	175/725 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 DALNNLPAREPVDME-------------------FKELSLTVKLGFNRGSKEILHNVCGK-FPGS 136
            |.:|::.|:|....|                   :|::..|:.  :..|.:.:|.||.|. .||:
Yeast   821 DNVNDIDAKEQFSSESSGANDEVFDDLEAKGVFIWKDVCFTIP--YEGGKRMLLDNVSGYCIPGT 883

  Fly   137 QLIAIMGPSGAGKSTLLDALSGFKTTGVDGSILLNGRRRDLPSFRRMSCYITQDDRLQPLLTVNE 201
             :.|:||.|||||:|||:.|:......:.|.:|:|||..| .||.|.:.|:.|.|.....|||.|
Yeast   884 -MTALMGESGAGKTTLLNTLAQRNVGIITGDMLVNGRPID-ASFERRTGYVQQQDIHIAELTVRE 946

  Fly   202 NMHIAADLKLGQTVSYEEKESRIEDILLLLGLYNHDQTLTMRLSGG----QKKRLSIAMELINNP 262
            ::..:|.::..|.:...||...:|.|:.:||:..:.:.|...:..|    |:|:|||.:||:..|
Yeast   947 SLQFSARMRRPQHLPDSEKMDYVEKIIRVLGMEEYAEALVGEVGCGLNVEQRKKLSIGVELVAKP 1011

  Fly   263 -TVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTAKLFQIFDQVYVL-SAGNCVYQ 325
             .::||||||:||||.|...:::||:||:..|::|:||||||:|.||:.||::.:| ..|..||.
Yeast  1012 DLLLFLDEPTSGLDSQSSWAIIQLLRKLSKAGQSILCTIHQPSATLFEEFDRLLLLRKGGQTVYF 1076

  Fly   326 GSTQK-----LVPFLQSVDLPCPMYHNPADYIIE-LACGEYGYDKVDTLKLATENGSCLTWFHNP 384
            |...|     |..|.::....|....|||:||:| :..|.....|.|..:         .|.::
Yeast  1077 GDIGKNSATILNYFERNGARKCDSSENPAEYILEAIGAGATASVKEDWHE---------KWLNS- 1131

  Fly   385 SAVLRAEVLMRKYPI--------PKKTKSR-----SLEDTSYSNQCSVLLRRGFIKAKRDTTMTH 436
                 .|....|..:        .::|||.     |...|||:.|...:|.|         |.|.
Yeast  1132 -----VEFEQTKEKVQDLINDLSKQETKSEVGDKPSKYATSYAYQFRYVLIR---------TSTS 1182

  Fly   437 LRIGVNIAVA----ALFGAMYDHTG----REGSRVLDNYNLLFAILMHHSMTTMMLTVLTFP--- 490
            ....:|..::    .|.|.:|  .|    ..|...:...|.:||        ..:..:|:.|
Yeast  1183 FWRSLNYIMSKMMLMLVGGLY--IGFTFFNVGKSYVGLQNAMFA--------AFISIILSAPAMN 1237

  Fly   491 --MDISILIKEHFN-RWYSLKAYYTAMTLV-----DLPISIISCFFFTVIVYLWSYQPM----EW 543
              ...:|..:|.|. |......::.::.|:     :||..:    ||:.|.::.||.|:    |.
Yeast  1238 QIQGRAIASRELFEVRESQSNMFHWSLVLITQYLSELPYHL----FFSTIFFVSSYFPLRIFFEA 1298

  Fly   544 IR---FFMFFSISLLTVFVGHSFGLMI--------GAWFDVVNGTFLAPVL-----TIPMMMFAG 592
            .|   :|:.:.|.....:||  .||||        .|  :|:.|..|:.:|     |.|:.:..|
Yeast  1299 SRSAVYFLNYCIMFQLYYVG--LGLMILYMSPNLPSA--NVILGLCLSFMLSFCGVTQPVSLMPG 1359

  Fly   593 F------------------GVTLRDLPSYLRWGSHISYL---------RYGLEGFISAIYGLDRG 630
            |                  |:.|...|...: ...::|.         .| ::.|:....|....
Yeast  1360 FWTFMWKASPYTYFVQNLVGIMLHKKPVVCK-KKELNYFNPPNGSTCGEY-MKPFLEKATGYIEN 1422

  Fly   631 TLACEEAPYCHYRYPKKFLEEITMRGDQFWN-----------DVIALGVMILVFR-----FVSYV 679
            ..|..:..||.|.....:|..|:.:....|.           ::||:..:..:|.     |:|.|
Yeast  1423 PDATSDCAYCIYEVGDNYLTHISSKYSYLWRNFGIFWIYIFFNIIAMVCVYYLFHVRQSSFLSPV 1487

  Fly   680 VLKAKIKSIR 689
            .:..|||:||
Yeast  1488 SILNKIKNIR 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	185/718 (26%)
		ABCG_EPDR	102..326	CDD:213180	88/249 (35%)
		ABC2_membrane	420..623	CDD:279410	53/268 (20%)
SNQ2	NP_010294.1	3a01205	103..1480	CDD:273362	181/706 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	5	4.940