DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and PEN3

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_176196.1	Gene:	PEN3 / 842281	AraportID:	AT1G59870	Length:	1469	Species:	Arabidopsis thaliana

Alignment Length:	646	Identity:	160/646 - (24%)
Similarity:	283/646 - (43%)	Gaps:	116/646 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GEVTSSRVYNSTTVPVGNSGGWRNAQSSVTPPPIPTPPQVNYTNGNEPSKQPPLEPVVEEEVHFD 90
            |||...|:...:....  |||..|.:..|.|          :|         ||....::..:|
plant   833 GEVAMGRMSRDSAAEA--SGGAGNKKGMVLP----------FT---------PLAMSFDDVKYF- 875

  Fly    91 TDALNNLPAREPVDM--EFKELSLT-VKLGFNRGSKEILHNVCGKFPGSQLIAIMGPSGAGKSTL 152
                        |||  |.::..:| .:|       ::|..|.|.|....|.|:||.|||||:||
plant   876 ------------VDMPGEMRDQGVTETRL-------QLLKGVTGAFRPGVLTALMGVSGAGKTTL 921

  Fly   153 LDALSGFKTTG-VDGSILLNGRRRDLPSFRRMSCYITQDDRLQPLLTVNENMHIAADLKLGQTVS 216
            :|.|:|.||.| ::|.:.::|..:...:|.|:|.|..|.|...|.:||.|::..:|.|:|.:.|.
plant   922 MDVLAGRKTGGYIEGDVRISGFPKVQETFARISGYCEQTDIHSPQVTVRESLIFSAFLRLPKEVG 986

  Fly   217 YEEKESRIEDILLLLGLYNHDQTL-----TMRLSGGQKKRLSIAMELINNPTVMFLDEPTTGLDS 276
            .:||...::.::.|:.|.:...::     ...||..|:|||:||:||:.||:::|:||||:|||:
plant   987 KDEKMMFVDQVMELVELDSLRDSIVGLPGVTGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDA 1051

  Fly   277 SSCTKVLELLKKLTSQGRTIICTIHQPTAKLFQIFDQVYVLS-AGNCVYQG----STQKLVPFLQ 336
            .:...|:..::.....|||::||||||:..:|:.||::.::. .|..:|.|    ::.|:|.:.:
plant  1052 RAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDELMLMKRGGQVIYAGPLGQNSHKVVEYFE 1116

  Fly   337 SVDLP----CPMYHNPADYIIELACGEYGYDKVDTLKLATENGSCLTWFHNPSAV-LRAEVLMRK 396
            |  .|    .|..:|||.:::|.:      .....|||:.:    ....:|.||: .|.:.|:::
plant  1117 S--FPGVSKIPEKYNPATWMLEAS------SLAAELKLSVD----FAELYNQSALHQRNKALVKE 1169

  Fly   397 YPIPKKTKSRSLEDTSYS----NQCSVLLRRGFIKAKRDTTMTHLRIGVNIAVAALFGAMYDHTG 457
            ..:|....|.....|.:|    .|....|.:.:....|......:|....:|.:.|.|.::...|
plant  1170 LSVPPAGASDLYFATQFSQNTWGQFKSCLWKQWWTYWRSPDYNLVRFIFTLATSLLIGTVFWQIG 1234

  Fly   458 REGSRVLD---NYNLLFAILMHHSMTTMMLTVLTFPMDISILIKEHFNRWYSLKAYYTAMTLVDL 519
            ...|...|   ....|:|.::...:...........::.::..:|.....||...|..:....:|
plant  1235 GNRSNAGDLTMVIGALYAAIIFVGINNCSTVQPMVAVERTVFYRERAAGMYSAMPYAISQVTCEL 1299

  Fly   520 PISIISCFFFTVIVYL-----WSYQPMEWIRFFMFFSISLLTVFVGHSFGLM------------- 566
            |..:|...::::|||.     |..:...|..|..:||....|.     :|:|
plant  1300 PYVLIQTVYYSLIVYAMVGFEWKAEKFFWFVFVSYFSFLYWTY-----YGMMTVSLTPNQQVASI 1359

  Fly   567 -IGAWFDVVNGTFLAPVLTIPMMMFAGFGVTLRDLPSYLRWGSHISYLRYGLEGFISAIYG 626
             ..|::.:.|             :|:||.:....:|.:..|...|..:.:.:.|.|.:.||
plant  1360 FASAFYGIFN-------------LFSGFFIPRPKIPKWWIWYYWICPVAWTVYGLIVSQYG 1407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	146/575 (25%)
		ABCG_EPDR	102..326	CDD:213180	82/233 (35%)
		ABC2_membrane	420..623	CDD:279410	39/224 (17%)
PEN3	NP_176196.1	PLN03140	31..1469	CDD:215599	160/646 (25%)
		ABC_trans_N	89..165	CDD:291196
		ABCG_PDR_domain1	154..426	CDD:213200
		ABC2_membrane	527..733	CDD:279410
		PDR_assoc	740..800	CDD:285559
		ABCG_PDR_domain2	864..1102	CDD:213199	85/257 (33%)
		ABC2_membrane	1197..1404	CDD:279410	39/224 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910