DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and abcg2d

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	XP_009292498.3	Gene:	abcg2d / 735310	ZFINID:	ZDB-GENE-050517-38	Length:	658	Species:	Danio rerio

Alignment Length:	682	Identity:	203/682 - (29%)
Similarity:	326/682 - (47%)	Gaps:	116/682 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 NGNEPSKQPPLEPVVEEEVHFDTDALNNLPAREPVDMEFKE----LSLTVKLGFNRGSKEILHNV 129
            ||...||...:||:.::  |..|.:.:::..|    :|.|.    ...||:       ||||.::
Zfish    19 NGQNGSKIIIMEPMKKQ--HGATVSFHSIRYR----VEQKTGPVCRRTTVQ-------KEILLDL 70

  Fly   130 CGKF-PGSQLIAIMGPSGAGKSTLLDALSGFK-TTGVDGSILLNGRRRDLPSFRRMSCYITQDDR 192
            .|.. ||  |.||:||:|:|||:.||.|:|.| ..|:.|.:|:||..:. .:|:.:|.|:.|||.
Zfish    71 NGIMRPG--LNAILGPTGSGKSSFLDVLAGRKDPAGLSGEVLVNGALQP-ANFKCLSGYVVQDDI 132

  Fly   193 LQPLLTVNENMHIAADLKLGQTVSYEEKESRIEDILLLLGLYNHDQT-----LTMRLSGGQKKRL 252
            :...|||.||:..:|.|:|...||..|||:|:..::..|||.....:     :...:|||::||.
Zfish   133 VMGTLTVRENLSFSAALRLSSHVSPREKEARVNHLISELGLNKVADSKVGTQIIRGISGGERKRT 197

  Fly   253 SIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTAKLFQIFDQVYVL 317
            ||.||||.:|:|:||||||||||:|:...||.|||::..||||||.:||||...::::||.:.:|
Zfish   198 SIGMELIIDPSVLFLDEPTTGLDASTAHSVLLLLKRMAGQGRTIIMSIHQPRFSIYRLFDSLTLL 262

  Fly   318 SAGNCVYQGSTQKLVPFLQSVDLPCPMYHNPADYIIELACGEYGYDKVDTLKLATENGSCLTWFH 382
            :.|..||.|..|..:.:..::...|..::||||:.:::.                 |||.:|...
Zfish   263 ANGKQVYHGPAQDALDYFSNIGYACEAHNNPADFFLDVI-----------------NGSSVTKIQ 310

  Fly   383 N-------PSAVLRAEV---LMRKYP---------------IPKKTKSRS---------LEDTSY 413
            |       .|||.|..|   ||.||.               |..|..|.|         ...:|:
Zfish   311 NNGDAECDVSAVSRQSVEDQLMEKYRSCSFARAVRAELDHIIQTKDSSSSSVAAECHSITYSSSF 375

  Fly   414 SNQCSVLLRRGFIKAKRDTTMTHLRIGVNIAVAALFGAMYDHTGREGSRVLDNYNLLFAILMHHS 478
            ..|...:|.|.|.....:...:..::.|...:||:.||::.....:.|.:.:.:.:||.|..:..
Zfish   376 CQQLRWVLWRTFWNLMLNPQTSVAQLAVTTLMAAIVGAIFYGVKDDQSGIQNRFGVLFFITTNQC 440

  Fly   479 MTTMMLTVLTFPMDISILIKEHFNRWYSLKAYYTAMTLVD------LPISIISCFFFTVIVYLWS 537
            .:|:....| |..:..:.|.|:.:.:|.:..::.:..|.|      :|..:.||    |:.::..
Zfish   441 FSTLSAAEL-FITERKLFIHEYTSGYYRVSVFFLSKILSDIITQRTIPSVLFSC----VVYFMIG 500

  Fly   538 YQPMEWIRFFMFFSISLLTVFVGHSFGLMIGAWFDVVN-GTFLAPVLTIPMMMFAGFGVTLRDLP 601
            .:|.. ..||:|....:|......:..:.|.|...||. ...|..|..|.||:|:|..|.|:.:.
Zfish   501 LKPTA-SAFFIFMLTVILVSCTAAAMAMAISADQSVVAVANILMTVSFIFMMIFSGLLVNLKSIM 564

  Fly   602 SYLRWGSHISYLRYGLEGF-ISAIYGLD-----RGTLACEEAPYCHYRYPKKFL-----EEITMR 655
            .:|.|..::|..|||||.. |:...||.     ..:||   :|..|      .|     :.:|.:
Zfish   565 DWLSWLKYLSIPRYGLEALEINEFVGLSFCGNVSESLA---SPAAH------VLMCTGEQHLTFQ 620

  Fly   656 GDQF-----WNDVIALGVMILVFRFVSYVVLK 682
            |..:     |.:.:||.||.|:|..::|:.|:
Zfish   621 GIDYSSWGLWQNHVALTVMTLIFLIIAYIKLR 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	195/654 (30%)
		ABCG_EPDR	102..326	CDD:213180	98/234 (42%)
		ABC2_membrane	420..623	CDD:279410	51/210 (24%)
abcg2d	XP_009292498.3	PRK10535	56..658	CDD:333000	192/639 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820