Protein Alignment CG5853 and ABCG8

DIOPT Version :9

• Sequence 1: NP_001260309.1
• Gene: CG5853 / 34322
• FlyBaseID: FBgn0032167
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: XP_011531331.1
• Gene: ABCG8 / 64241
• HGNCID: 13887
• Length: 677
• Species: Homo sapiens
• Alignment Length: 762
• Identity: 184/762 - (24%)
• Similarity: 316/762 - (41%)
• Gaps: 180/762 - (23%)

  Fly     4 PREQFLFGSDNGVAGLGLGIEIGEVTSSRVYNSTTVPVGNSGGWRNAQSSVTPPPIPTPPQVNYT 68
            |.|..|..|.....||||        ..|:::|.:   .||                    :.:|
Human    10 PAESALLQSSLRSTGLGL--------QDRLFSSES---DNS--------------------LYFT 43

  Fly    69 NGNEPSKQPPLEPVVEEEVHFDTDALNNLPAREPVDMEFK------ELSLTVKLGFNRGSKEILH 127
            ...:|:   .||   ..::::..|..:.:|..|.: .:||      ....:.:||        :.
Human    44 YSGQPN---TLE---VRDLNYQVDLASQVPWFEQL-AQFKMPWTSPSCQNSCELG--------IQ 93

  Fly   128 NVCGKFPGSQLIAIMGPSGAGKSTLLDALSGFKTTG--VDGSILLNGRRRDLPSFRRMSCYITQD 190
            |:..|....|::||:|.||.|:::|||.::|....|  ..|.|.:||:.......|:...::.|.
Human    94 NLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQH 158

  Fly   191 DRLQPLLTVNENMHIAADLKLGQTVSYEEKESRIEDILLLLGLYNHDQT----LTMR-LSGGQKK 250
            ::|.|.|||.|.:...|.::|.:|.|..:::.|:||::..|.|.....|    :.:| ||||:::
Human   159 NQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERR 223

  Fly   251 RLSIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTAKLFQIFDQVY 315
            |:||.::|:.||.::.|||||:||||.:...:::.|.:|....|.::.::|||.:.:|::||.|.
Human   224 RVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVL 288

  Fly   316 VLSAGNCVYQGSTQKLVPFLQSVDLPCPMYHNPADYIIELACGEYGYDKVD----TLKLAT-ENG 375
            ::::|..:|.|:.|.:|.:..::..|||.|.||||:.::|.       .:|    ..:||| |..
Human   289 LMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLT-------SIDRRSREQELATREKA 346

  Fly   376 SCLTWFHNPSAVLRAEVLMRKYPIPKKTKSRSL-EDTSYSN---------------------QCS 418
            ..|       |.|..|.:........|.:::.| |||...:                     |.:
Human   347 QSL-------AALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFT 404

  Fly   419 VLLRRGFIKAKRD--TTMTHLRIGVNIAVAAL-FGAMYDHTGREGSRVLDNYNLLFAILMHHSMT 480
            .|:||......||  |.:.|   |....:.:: .|.:|...|......:|...|||
Human   405 TLIRRQISNDFRDLPTLLIH---GAEACLMSMTIGFLYFGHGSIQLSFMDTAALLF--------- 457

  Fly   481 TMMLTVLTFPMDISILIKEHFNR---WYSLK-------AYYTAMTLVDLPISIISCFFFTVIVYL 535
             |:..::.|.:.:.::.|.:..|   :|.|:       .|:.|..|.:||   ..|.:  :|:|
Human   458 -MIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELP---EHCAY--IIIY- 515

  Fly   536 WSYQPMEWIR--------FFMFFSISLLTVFVGHSFGLMIGAWFDVVN-GTFLAPVLTIPMMMFA 591
              ..|..|:.        |.:.|.:..|.||......|...|.....: .:|.:..|.....:..
Human   516 --GMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAG 578

  Fly   592 GFGVTLRDLPSYLRWGSHISYLRYGLEG-----FISAIYGLDRGTLACEEAPYCHYRYPKKFLEE 651
            ||.:.|..|.:...|.|.:|:||:..||     |....|.:..|.|.
Human   579 GFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLT------------------ 625

  Fly   652 ITMRGDQ--------------FWNDVIALGVMILVFRFVSYVVLKAK 684
            |.:.||:              .:..||.|....:|..:||...:|.|
Human   626 IAVSGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYVSLRFIKQK 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	167/669 (25%)
		ABCG_EPDR	102..326	CDD:213180	72/236 (31%)
		ABC2_membrane	420..623	CDD:279410	52/229 (23%)
ABCG8	XP_011531331.1	ABCG_White	64..299	CDD:213201	74/243 (30%)
		3a01204	92..667	CDD:273361	159/627 (25%)
		ABC2_membrane	406..610	CDD:279410	51/224 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720