Protein Alignment CG5853 and ABCG5

DIOPT Version :9

• Sequence 1: NP_001260309.1
• Gene: CG5853 / 34322
• FlyBaseID: FBgn0032167
• Length: 689
• Species: Drosophila melanogaster
• Sequence 2: NP_071881.1
• Gene: ABCG5 / 64240
• HGNCID: 13886
• Length: 651
• Species: Homo sapiens
• Alignment Length: 621
• Identity: 162/621 - (26%)
• Similarity: 290/621 - (46%)
• Gaps: 98/621 - (15%)

  Fly   122 SKEILHNVCGKFPGSQLIAIMGPSGAGKSTLLDALSG-FKTTGVD-GSILLNGRRRDLPSFRRMS 184
            :::||.:|.......|::.|:|.||:||:|||||:|| ....|.. |.:.:|||......|:...
Human    65 TRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCF 129

  Fly   185 CYITQDDRLQPLLTVNENMHIAADLKL--GQTVSYEEK-ESRIEDILL------LLGLYNHDQTL 240
            .|:.|.|.|...|||.|.:|..|.|.:  |...|:::| |:.:.::.|      |:|.|:
Human   130 SYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNYS----- 189

  Fly   241 TMRLSGGQKKRLSIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTA 305
            ...:|.|:::|:|||.:|:.:|.||..||||||||..:..:::.||.:|..:.|.::.|||||.:
Human   190 LGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRS 254

  Fly   306 KLFQIFDQVYVLSAGNCVYQGSTQKLVPFLQSVDLPCPMYHNPADYIIELACGEYGYDKVDTLKL 370
            :|||:||::.:||.|..::.|:..:::.|......|||.:.||.|:.::|.       .|||...
Human   255 ELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLT-------SVDTQSK 312

  Fly   371 ATE----------------NGSCLTWFHNPSAVLRAEVLMRKYPIPKKTKSRSLEDTSYSNQCSV 419
            ..|                :..|.....|   :.|.:.|.....:|.|||    :.....::..|
Human   313 EREIETSKRVQMIESAYKKSAICHKTLKN---IERMKHLKTLPMVPFKTK----DSPGVFSKLGV 370

  Fly   420 LLR---RGFIKAKRDTTMTHLRIGVNIAVAALFGAMYDHTGREGSRVL-----DNYNLLFAILMH 476
            |||   |..::.|. ..:|.|...:.:.:..||..:     |..|.||     |...||:..:..
Human   371 LLRRVTRNLVRNKL-AVITRLLQNLIMGLFLLFFVL-----RVRSNVLKGAIQDRVGLLYQFVGA 429

  Fly   477 HSMTTMMLTVLTFPMDISILIKEH----FNRWYSLKAYYTAMTLVDLPISIISCFFFTVIVYLWS 537
            ...|.|:..|..||:..::..:|.    :.:|..:.||    .|..||.|:::...|:.:.| |:
Human   430 TPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAY----ALHVLPFSVVATMIFSSVCY-WT 489

  Fly   538 YQPMEWIRFFMFFSISLLTVFVGHSFG-----LMIGAWFDVVNGTFLAPVLTI----PMMMFAGF 593
            ......:..|.:||.:||   ..|..|     :::|.   |.|...:..|:.:    .:::.:||
Human   490 LGLHPEVARFGYFSAALL---APHLIGEFLTLVLLGI---VQNPNIVNSVVALLSIAGVLVGSGF 548

  Fly   594 GVTLRDLPSYLRWGSHISYLRYGLEGF-ISAIYGLD----RGTLACEEAPYCHYRYPKKFLEE-- 651
            ...::::|...:..|:.::.:|..|.. ::..|||:    ...::....|.|.:....:|:|:
Human   549 LRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSNVSVTTNPMCAFTQGIQFIEKTC 613

  Fly   652 ------ITMRGDQFWNDVIALGVM-ILVFRFVSYVV 680
                  .||.....::.:.||.:: |:||:...:::
Human   614 PGATSRFTMNFLILYSFIPALVILGIVVFKIRDHLI 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	162/621 (26%)
		ABCG_EPDR	102..326	CDD:213180	77/214 (36%)
		ABC2_membrane	420..623	CDD:279410	49/224 (22%)
ABCG5	NP_071881.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		ABCG_White	50..275	CDD:213201	77/214 (36%)
		3a01204	60..645	CDD:273361	162/615 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920