DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and abcg2c

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	XP_005156580.1	Gene:	abcg2c / 569858	ZFINID:	ZDB-GENE-050517-37	Length:	640	Species:	Danio rerio

Alignment Length:	672	Identity:	193/672 - (28%)
Similarity:	309/672 - (45%)	Gaps:	118/672 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 EPVVEEEVHFDTDALNNLPARE---PVDMEFKELSLTVK--LGF---NRGSKEILHNVCGKF-PG 135
            |.||.|:  ..|||..::|..:   |. :.|.::...:|  ||.   ....|:||.:|.|.. ||
Zfish    10 EVVVNEQ--SSTDADESVPCFQTPGPT-VTFHQIRYRIKERLGMFSCQWREKDILKDVSGIMNPG 71

  Fly   136 SQLIAIMGPSGAGKSTLLDALSGFK-----TTG---VDGSILLNGRRRDLPSFRRMSCYITQDDR 192
              :.|||||:|:||::|||.::|.|     .:|   ||.:|:.:    ||   |..|.|:.|:|.
Zfish    72 --MNAIMGPTGSGKTSLLDVIAGRKDPKGLKSGQVLVDNTIVTS----DL---RLCSAYVVQNDI 127

  Fly   193 LQPLLTVNENMHIAADLKLG-QTVSYEEKESRIEDILLLLGLYNHDQTL--TMRL---SGGQKKR 251
            |...|||.||:..:|:|:|. :..|..:||.|:..::..|||.:...|.  ||.|   |||:|||
Zfish   128 LMGTLTVRENLAFSANLRLSLKEYSSSDKEMRVNSVIQELGLKDCADTKIGTMFLRGVSGGEKKR 192

  Fly   252 LSIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTAKLFQIFDQVYV 316
            .||.||||.:|:::||||||||||:::...::|||:.::.:|:|:|.:||||...:|:.||.:.:
Zfish   193 CSIGMELITSPSLLFLDEPTTGLDANTANSIMELLQNISKKGKTVIFSIHQPRYSIFRQFDHLTL 257

  Fly   317 LSAGNCVYQGSTQKLVPFLQSVDLPCPMYHNPADYIIELACGEYG--------YDKVDTLKLATE 373
            ::.|..:|.|:..|.:.:.:.:...|..::||||:.:::..|...        .:|..:.:...:
Zfish   258 MNKGEIIYAGAADKAIIYFEDLGYKCEPFNNPADFFLDVTNGTIRPHKSSNNISEKCSSSEEMVD 322

  Fly   374 NGSCLTWFHNPSAVLRAEVLMRKYPIPKKTKSRSLE-----------------DTSYSNQCSVLL 421
            |       .||.|     |:.||.|...|.|.|..|                 .|.:..|..::.
Zfish   323 N-------ENPLA-----VMYRKSPYFTKLKDRLTEISDGLDPEVTKGDKIGYATPFYYQLLLVS 375

  Fly   422 RRGFIKAKRDTTMTHLRIGVNIAVAALFGAMY---DHTGREGSRVLDNYNLLFAILMHHSMTTMM 483
            .|......|:...::.::.:||....|.|.:|   .||..|   .|.|....|..|:.:.:...:
Zfish   376 GRTIRNILRNPQTSYAQLFLNIFFGILVGLIYYQIPHTLPE---ALQNRTGAFFFLVINMVFGNL 437

  Fly   484 LTVLTFPMDISILIKEHFNRWYSLKAYYTAMTLVDL-PISIISCFFFTVIVYLWSYQPMEWIRFF 547
            ..|..|..:..:.|.|:.:.:|...||:.:....|| |..|:..|.|:.|.|.......|...||
Zfish   438 SAVELFVSERELFIHENSSGFYRTSAYFLSKVFADLIPNRILPVFIFSAIPYFMMGLKPEVEAFF 502

  Fly   548 MF----FSISLLTVFVGHSFGLMIGAWFDVVNGTFLAPVLTIPMMMFAGFGVTLRDLPSYLRWGS 608
            ::    ..:||..|.:.......:|: |.:.|.....|.  :.||:|.||.|.|..:.|.|.|..
Zfish   503 LYCVTMSMVSLSAVSLAFLVSASVGS-FAMANILIALPY--VFMMVFGGFLVNLNSMLSGLSWLK 564

  Fly   609 HISYLRYGLEGFISAIYGLDRGTLACEEAPYCHYRYPKKFLEEIT-MRGDQ-------------F 659
            ..|..|||.            ..||..|..      .:.|.:.:| :.||.             |
Zfish   565 WASIFRYGY------------NALAINELK------DQVFTDNLTRVTGDMYLDHQEIDRSAWGF 611

  Fly   660 WNDVIALGVMILVFRFVSYVVL 681
            |.:.:||..::.|...::||.|
Zfish   612 WENQVALAGIMFVCLILAYVQL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	186/655 (28%)
		ABCG_EPDR	102..326	CDD:213180	94/243 (39%)
		ABC2_membrane	420..623	CDD:279410	53/210 (25%)
abcg2c	XP_005156580.1	ABCG_EPDR	34..267	CDD:213180	93/242 (38%)
		3a01204	37..638	CDD:273361	184/642 (29%)
		ABC2_membrane	377..579	CDD:279410	55/219 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750