DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and abcg4a

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	XP_687685.2	Gene:	abcg4a / 564842	ZFINID:	ZDB-GENE-050517-39	Length:	641	Species:	Danio rerio

Alignment Length:	656	Identity:	280/656 - (42%)
Similarity:	404/656 - (61%)	Gaps:	32/656 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 AQSSVTPPPIPTPPQVNYTNGNEPSKQPPLEPVVEEEVHF-DTDALNNLPAREPVDMEFKELSLT 113
            |:.::.|..:..|.:.....|.:.:....|:.|   |.|. :....::||.|..||:||.|||.|
Zfish     2 AEKTLEPGSVSIPMEETKRAGGDAAMLTHLKKV---ENHITEAQRFSHLPRRSTVDLEFTELSYT 63

  Fly   114 VKLG---FNRGSKEILHNVCGKFPGSQLIAIMGPSGAGKSTLLDALSGFKTTGVDGSILLNGRRR 175
            ::.|   ..||.|.:|..:.|||...:||.||||||||||||::.|:|::.||:.|.||:|||.|
Zfish    64 IREGPCWRRRGFKALLKCLSGKFCSRELIGIMGPSGAGKSTLMNILAGYRETGMKGQILVNGRPR 128

  Fly   176 DLPSFRRMSCYITQDDRLQPLLTVNENMHIAADLKLGQTVSYEEKESRIEDILLLLGLYNHDQTL 240
            ||.:||:|||||.|||.|.|.||..|.|.::|:|||.:.:  |.|:..:.:||..|||....||.
Zfish   129 DLRTFRKMSCYIMQDDMLLPHLTTREAMMVSANLKLNENM--EVKKELVNEILTALGLQECAQTR 191

  Fly   241 TMRLSGGQKKRLSIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTA 305
            |:.|||||.|||:||:||:|||.|||.||||:||||:||.:|:.|:|.|...|||||||||||:|
Zfish   192 TISLSGGQCKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSA 256

  Fly   306 KLFQIFDQVYVLSAGNCVYQGSTQKLVPFLQSVDLPCPMYHNPADYIIELACGEYGYDKVDTLKL 370
            |||::||::|:||.|.|:|:|:...|:|:|:::.|.||.||||||:|||:|.|||| |....|..
Zfish   257 KLFEMFDKLYILSQGQCIYKGTVPYLIPYLKNLGLHCPTYHNPADFIIEVASGEYG-DLNPVLFE 320

  Fly   371 ATENGSC-------LTWFHNPSAVLRAEVLMRKYP----IPKKTKSRSLEDTSYSNQCSVLLRRG 424
            |.:.|.|       .:..::|:....::.    ||    |.|.|.:     ||...|..:|.:|.
Zfish   321 AVQGGLCSDDSKKNSSDKNDPTTSCPSQC----YPDSGYIEKHTFA-----TSTLTQFCILFKRT 376

  Fly   425 FIKAKRDTTMTHLRIGVNIAVAALFGAMYDHTGREGSRVLDNYNLLFAILMHHSMTTMMLTVLTF 489
            ||...||..:||||:..::.:..|.|.:|.:.|.:.|:|.:|...||..::......:|.|||||
Zfish   377 FITICRDVVLTHLRVMSHLCIGVLIGLLYLNIGNDASKVFNNTGFLFFSMLFLMFAALMPTVLTF 441

  Fly   490 PMDISILIKEHFNRWYSLKAYYTAMTLVDLPISIISCFFFTVIVYLWSYQPMEWIRFFMFFSISL 554
            |:::.:.|:||.|.||||||||.|.|:.|:|..:|....:..|||..:.||.|..|:.:|.::|.
Zfish   442 PLEMGVFIREHLNYWYSLKAYYLAKTMADIPFQVICPIMYCSIVYWMTEQPPEAGRYLLFMALST 506

  Fly   555 LTVFVGHSFGLMIGAWFDVVN-GTFLAPVLTIPMMMFAGFGVTLRDLPSYLRWGSHISYLRYGLE 618
            .|..|..|.||:|||....:. .||:.||..||:::|:||.|....:|.||:|.|::||:|||.|
Zfish   507 STALVAQSLGLLIGAASTSLQVATFVGPVSAIPVLLFSGFFVNFDTIPKYLQWSSYVSYVRYGFE 571

  Fly   619 GFISAIYGLDRGTLACEEAPYCHYRYPKKFLEEITMRGDQFWNDVIALGVMILVFRFVSYVVLKA 683
            |.|.:|||::|..|.| ....|.::.|::.|:.:.:...:.:.|.:.|||..||.|..:|.||:.
Zfish   572 GVILSIYGMNRSELEC-PGIVCKFQKPEEVLQLLDVEDAKLYVDFMVLGVFFLVLRLATYFVLRY 635

  Fly   684 KIKSIR 689
            |:||.|
Zfish   636 KVKSER 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	271/606 (45%)
		ABCG_EPDR	102..326	CDD:213180	128/226 (57%)
		ABC2_membrane	420..623	CDD:279410	83/203 (41%)
abcg4a	XP_687685.2	3a01204	38..641	CDD:273361	271/615 (44%)
		ABCG_EPDR	53..277	CDD:213180	128/225 (57%)
		ABC2_membrane	372..574	CDD:279410	82/201 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5116
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm25175
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.950