DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and Abca15

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_796187.2	Gene:	Abca15 / 320631	MGIID:	2388709	Length:	1668	Species:	Mus musculus

Alignment Length:	846	Identity:	167/846 - (19%)
Similarity:	286/846 - (33%)	Gaps:	254/846 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 NYTNGNEPSKQPPLEPVVE--EEVHFDTDALNNLPAREPVDM----EFKELSLTVKLGFNRGSKE 124
            :|..|..|.::..:....|  |..:|:.         ||.|:    :.|.|....:.  |..:|.
Mouse   486 SYWFGEPPQQKLEITQFYERVESKYFEA---------EPTDLTAGIQIKHLHKVFQK--NNTTKV 539

  Fly   125 ILHNVCGKFPGSQLIAIMGPSGAGKSTLLDALSGFKTTGVDGSILLNGR--RRDLPSFRRMSCYI 187
            .:.::.......|:..::|.:||||||.|..|||.... ..|...::|.  .:.:...|......
Mouse   540 AIKDLSLNLYEGQVTVLLGHNGAGKSTTLSILSGLYPP-TSGEAYVHGEDISQHMDQVRNSLGLC 603

  Fly   188 TQDDRLQPLLTVNENMHIAADLK-LGQTVSYEEKESRIEDILLLLGLYNHDQTLTMRLSGGQKKR 251
            .|.:.|...|||:|:::....:| :.|.:..||    ..::|....|.......:..||||.|::
Mouse   604 PQQNLLFDHLTVSEHLYFYCRIKGVPQKMYLEE----TNNMLSAFNLMEKCDAFSKSLSGGMKRK 664

  Fly   252 LSIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIH-QPTAKLFQIFDQVY 315
            |:|.:.||....|..|||||:|:|.:|.....::|:.. .|.|||:.|.| ...|.:  :.|::.
Mouse   665 LAIIIALIGGSKVAILDEPTSGMDPASRRSTWDILQTY-KQNRTILLTTHYMDEADV--LGDRIA 726

  Fly   316 VLSAGNCVYQGSTQKLVPFLQSVDLPCPMYHNPADYIIELACGEYGYDKVDTLKLATENGSCLTW 380
            ::..|.....||: ..:..|..|.....|...|...|.|::...:.|  |.|..|.|..|:.|::
Mouse   727 IMVRGTLRCCGSS-VFLKRLYGVGSHLVMVKEPYCDIAEISKLIHSY--VPTATLETNVGNELSF 788

  Fly   381 F------HNPSAVLRA---------------------EVLMR-------KYPIPKKTKSRSL--- 408
            .      |...|:..|                     ||.::       |..| :.|:|.|:
Mouse   789 ILPKEYTHRFEALFTALEENQENLGISSFGVSITTMEEVFLKVSNLEDSKTDI-EATQSPSVGSK 852

  Fly   409 -------------------EDTS--YSNQCSVLLR-----------------RGF---------- 425
                               ||.:  ::..||:.|:                 ||.
Mouse   853 GNKNGDVESSGRVGFPTQSEDQNIVFNTGCSLYLQQFRAMFMKRLMYNWRNWRGILVQILGLIIS 917

  Fly   426 -------------------------------IKAKRDTT---MTHLR------------------ 438
                                           |..|.:.|   :|||.
Mouse   918 TFLLLKSHEFRYKKIRQMNLDEYGQTIVPFSIWGKSNLTSSLLTHLENMLKPGNHQLKEVQGDLL 982

  Fly   439 --------------IGVNIAVAA-------LFGAMYDHTGREGSRVLDNYNLLFAILMHHSMTTM 482
                          |.::|.|.|       ||.....|:......|||  |:||   |..|.:..
Mouse   983 KYLEGNDECVHLCVIALSIKVVANRVNLTVLFNNEAYHSPSLSLTVLD--NILF---MSLSGSDA 1042

  Fly   483 MLTVLTFP-----------------------MDISILIK--------EHFNR--------WYSLK 508
            .:||...|                       :.:::|:.        |..|:        ..|:.
Mouse  1043 SITVFNKPQPSPQRKEWPGSTDGKIVAFKIQLGMALLVSGFCILTVTERHNKTKHMQFLSGVSIL 1107

  Fly   509 AYYTAMTLVDLPISIISCFFFTVI-------VYLWSYQPMEWIRFFMFFSISL--LTVFVGHSFG 564
            .|:.:..:.||.|..|||.|..|:       :|:..|..::.:.....|..|.  ||..:...|.
Mouse  1108 VYWLSALVFDLIIFFISCCFLLVMFKYCKFDIYVTDYHILDTMLILTLFGWSAIPLTYLLSFLFS 1172

  Fly   565 LMIGAWFDVVNGTFLAPVLTIPM--MMFAGFGVTLRDLPSYLRWGSHISYLRYGLEGFISAIYGL 627
            ....|:.:::...:|:..|::.|  ::.|.....:.:........:.:.:..|.|...||....:
Mouse  1173 KSNSAYINLLVFCYLSGTLSLLMDTIIEARISTIMSNSTQTFLLNALLLFPMYNLGKCISEYTVI 1237

  Fly   628 DRGTLACEEAP------YCHYRYPKKFLEEI--TMRGDQFWNDVIALGVMILVFRFVSYVVLKAK 684
            .|..:.|.:..      .|..::.||.:..:  .|.|.......||..|.:|:..|...:..|.|
Mouse  1238 YRKKMLCIQQKNALKYLNCSNKHTKKNIYSLKKPMLGKYLIAMSIAGFVFLLLIFFWENISWKVK 1302

  Fly   685 I 685
            :
Mouse  1303 M 1303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	161/813 (20%)
		ABCG_EPDR	102..326	CDD:213180	61/231 (26%)
		ABC2_membrane	420..623	CDD:279410	55/352 (16%)
Abca15	NP_796187.2	ABC2_membrane_3	144..464	CDD:289468
		ABC2_membrane	<267..383	CDD:304374
		CcmA	522..831	CDD:224054	79/321 (25%)
		ABC_subfamily_A	522..743	CDD:213230	61/231 (26%)
		ABC2_membrane_3	<1009..1231	CDD:289468	41/226 (18%)
		CcmA	1354..1648	CDD:224054
		ABC_subfamily_A	1354..1575	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000