DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5853 and Abca12

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	XP_237242.6	Gene:	Abca12 / 301482	RGDID:	1304586	Length:	2595	Species:	Rattus norvegicus

Alignment Length:	760	Identity:	174/760 - (22%)
Similarity:	284/760 - (37%)	Gaps:	253/760 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 VDMEFKELSLTVKL-GFNR--GSKEILHNVCGKFPGSQLIAIMGPSGAGKSTLLDALSG-FKTTG 163
            ::.|.|:|.:.|.| |..:  |||..:.|:...|....:.:::||:||||:|.:..|:| |..|.
  Rat  1335 IEPEPKDLQVGVALHGVTKSYGSKTAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGATA 1399

  Fly   164 VDGSILLNGR--RRDLPSFRRMSCYITQDDRLQPLLTVNENMHIAADLKLGQTVS---YEEKESR 223
              |:|.:.|:  :.||.:.|:......|.|.|...||..|::.:...:|:.....   :||.:..
  Rat  1400 --GTIFVYGKDIKTDLNTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRT 1462

  Fly   224 IEDILLLLGLYNHDQTLTMRLSGGQKKRLSIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKK 288
            ::|    .|||:|.......||||.|::|||::.||....|:.||||:||:|..|...:.:::.|
  Rat  1463 LKD----TGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK 1523

  Fly   289 LTSQGRTIICTIHQPTAKLFQIFDQVYVLSAGNCVYQGSTQKLVPFLQSVDLPC---PMYHNPAD 350
             ....||||.:.|.        .|:..|||           ..:.||:...|.|   |.|
  Rat  1524 -NKTARTIILSTHH--------LDEAEVLS-----------DRIAFLEQGGLRCCGSPFY----- 1563

  Fly   351 YIIELACGEYGYDKVDTLKLATE---NGSC-------LTWFHNPSAVLRAEV---LMRKYPIPKK 402
              ::.|.|: ||....|.|.:..   |..|       :...|.|.|.|:.::   |:...| |..
  Rat  1564 --LKEAFGD-GYHLTLTKKKSPNLDTNAICDTVAVTAMIQSHLPEAYLKEDIGGELVYVLP-PFS 1624

  Fly   403 TK--------SRSLE--------------DTSYSNQCSVLLRRGFIKAKRDT------TMTHL-- 437
            ||        .|:|:              ||:        :...|:...:|:      ::.||
  Rat  1625 TKVSGAYLSLLRALDKGMGKLNIGCYGISDTT--------VEEVFLNLTKDSQKCGNMSLEHLTQ 1681

  Fly   438 -RIGVNIAVAA-----LFGAMYDHTGREG-----SRVLDNYNLL----FAILM---HHS------ 478
             ::|...|...     |..:..:.|.|:.     |..||.:.||    .|||:   ||:
  Rat  1682 RKVGNPSANGTSTPDDLSVSSSNFTDRDDKVLTRSERLDGFGLLLKKIMAILIKRFHHTRRNWKG 1746

  Fly   479 ------------MTTMMLTVL-----------------------------------------TFP 490
                        .|.|.|..|                                         .||
  Rat  1747 LIAQVVLPIVFVATAMGLGTLRDSSNSYPELLISPSIYGNSEQTAFYANFDPSTNALVSALWNFP 1811

  Fly   491 ---------MDISILIKEHFNRWYSLKAYYTAMTLVDLPISIISC------------------FF 528
                     .|...|.|::..:|      .|:...:| ...:.||                  .:
  Rat  1812 GIDNVCLNTSDSQCLKKDNLGKW------NTSGEAID-NFGVCSCSDNVQECPKFNYSPPHRRTY 1869

  Fly   529 FTVIVYLWSYQPMEWIRFFMFFSISLLTVFV-----GHSFGLMI--GAWFDV----VNGTFLAPV 582
            .:.::|..:.:.||      .:.||....||     |.|||:.:  ...|||    ||.| ||.|
  Rat  1870 SSQVIYNLTGKHME------NYLISTANHFVQKRYGGWSFGMKLTNDLRFDVTAVPVNRT-LAKV 1927

  Fly   583 LTIPMMMFAGFGVTLRDLPSYLRWGSHISYLRYGLEGFISAIYGLDRGTLACEEAPYCHYRYP-K 646
            ...|    .|:    ..||:||...::. .||..:..:.:|.:|:         ..|.| .|| .
  Rat  1928 WYDP----EGY----HSLPAYLNSLNNF-LLRVNMSEYDAARHGI---------IMYSH-PYPGV 1973

  Fly   647 KFLEEITMRGDQFWNDVIALGVM----ILVFRFVSYVVLKAKIKS 687
            :..|:.|:  ....:.::||.::    :....||:|:|.:.:.|:
  Rat  1974 QDQEQATI--SSLIDILVALSILMGYSVTTASFVTYIVREHQTKA 2016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	174/760 (23%)
		ABCG_EPDR	102..326	CDD:213180	71/231 (31%)
		ABC2_membrane	420..623	CDD:279410	61/325 (19%)
Abca12	XP_237242.6	ABC2_membrane_3	<1006..1267	CDD:289468
		NosY	<1108..1269	CDD:224196
		ZnuC	1346..1570	CDD:224046	75/256 (29%)
		ABC_subfamily_A	1350..1565	CDD:213230	72/247 (29%)
		ABC2_membrane_3	<1913..2174	CDD:289468	32/126 (25%)
		CcmA	2253..2567	CDD:224054
		ABC_subfamily_A	2254..2477	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000