DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and Abcg5

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_114090.1	Gene:	Abcg5 / 27409	MGIID:	1351659	Length:	652	Species:	Mus musculus

Alignment Length:	676	Identity:	179/676 - (26%)
Similarity:	322/676 - (47%)	Gaps:	102/676 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 PPLEPVVEEEVHFDTDALNNL--------PAREPVDMEFKELSLTVKLG--FN------RGSKEI 125
            |.|.|......|.:..:|::|        .||..:.:.....|::.::|  :|      :..::|
Mouse     5 PFLSPEGARGPHINRGSLSSLEQGSVTGTEARHSLGVLHVSYSVSNRVGPWWNIKSCQQKWDRQI 69

  Fly   126 LHNVCGKFPGSQLIAIMGPSGAGKSTLLDALSG-FKTTG-VDGSILLNG--RRRDLPSFRRMSCY 186
            |.:|.......|::.|:|.||:||:|||||:|| .:.|| ::|.:.:||  .|||  .|:....|
Mouse    70 LKDVSLYIESGQIMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRD--QFQDCFSY 132

  Fly   187 ITQDDRLQPLLTVNENMHIAADLKLGQTVS--YEEK-ESRIEDILL------LLGLYNHDQTLTM 242
            :.|.|.....|||.|.:...|.|.|.::.:  |.:| |:.:.::.|      ::|.||..
Mouse   133 VLQSDVFLSSLTVRETLRYTAMLALCRSSADFYNKKVEAVMTELSLSHVADQMIGSYNFG----- 192

  Fly   243 RLSGGQKKRLSIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTAKL 307
            .:|.|:::|:|||.:|:.:|.||.|||||||||..:..:::.||.:|..:.|.:|.|||||.::|
Mouse   193 GISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANQIVLLLAELARRDRIVIVTIHQPRSEL 257

  Fly   308 FQIFDQVYVLSAGNCVYQGSTQKLVPFLQSVDLPCPMYHNPADYIIELACGE--------YGYDK 364
            ||.||::.:|:.|..|:.|:.::::.|..:...|||.:.||.|:.::|...:        ..|.:
Mouse   258 FQHFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDTQSREREIETYKR 322

  Fly   365 VDTLKLATENGSCLTWFHN-PSAVLRAEVLMRKYPIPKKTKSRSLEDTSYSNQCSVLLRRGFIKA 428
            |..|:.|.:....   :|. ...:.||..|.....:|.|||    :......:..|||||.....
Mouse   323 VQMLECAFKESDI---YHKILENIERARYLKTLPTVPFKTK----DPPGMFGKLGVLLRRVTRNL 380

  Fly   429 KRDTTMTHLRIGVNIAVAALFGAMY----DHTGREGSRVLDNYNLLFAILMHHSMTTMMLTVLTF 489
            .|:.....:|:..|: :..||...|    .:...:|: |.|...||:.::.....|.|:..|..|
Mouse   381 MRNKQAVIMRLVQNL-IMGLFLIFYLLRVQNNTLKGA-VQDRVGLLYQLVGATPYTGMLNAVNLF 443

  Fly   490 PMDISILIKEH----FNRWYSLKAYYTAMTLVDLPISIISCFFFTVIVYLWSYQPMEWIRFFMFF 550
            ||..::..:|.    :::|..|.||    .|..||.|:|:...|:.:.| |:......:..|.:|
Mouse   444 PMLRAVSDQESQDGLYHKWQMLLAY----VLHVLPFSVIATVIFSSVCY-WTLGLYPEVARFGYF 503

  Fly   551 SISLLTV-FVGHSFGLMIGAWF---DVVNGTFLAPVLTIP-MMMFAGFGVTLRDLPSYLRWGSHI 610
            |.:||.. .:|....|::....   ::||.  :..:|:|. :::.:||...::::|..|:...:.
Mouse   504 SAALLAPHLIGEFLTLVLLGIVQNPNIVNS--IVALLSISGLLIGSGFIRNIQEMPIPLKILGYF 566

  Fly   611 SYLRYGLEGF-ISAIYGLDRGTLACEEA-------PYCHYRYPKKFLEE-------------ITM 654
            ::.:|..|.. ::..|||:   ..|..:       |.|......:|:|:             :.:
Mouse   567 TFQKYCCEILVVNEFYGLN---FTCGGSNTSMLNHPMCAITQGVQFIEKTCPGATSRFTANFLIL 628

  Fly   655 RGDQFWNDVIALGVMILVFRFVSYVV 680
            .|  |...::.||  |::|:...|::
Mouse   629 YG--FIPALVILG--IVIFKVRDYLI 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	174/656 (27%)
		ABCG_EPDR	102..326	CDD:213180	83/244 (34%)
		ABC2_membrane	420..623	CDD:279410	51/216 (24%)
Abcg5	NP_114090.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		5/19 (26%)
		ABCG_White	50..276	CDD:213201	82/232 (35%)
		3a01204	61..646	CDD:273361	167/614 (27%)
		ABC2_membrane	372..579	CDD:279410	51/215 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820