DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and Abca7

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_001334010.1	Gene:	Abca7 / 27403	MGIID:	1351646	Length:	2167	Species:	Mus musculus

Alignment Length:	332	Identity:	91/332 - (27%)
Similarity:	144/332 - (43%)	Gaps:	55/332 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PPPIPTPPQVNYTNGNEPSKQPPLEPVVEE-EVHFDTDALNNLPAREPVDMEFKELSLT-VKLGF 118
            |.|...|.:.:|..|..|.|...|.|..:: :|..:...|..:|.          :|:. :|..|
Mouse   759 PEPWNFPFRRSYWCGPGPPKSSVLAPAPQDPKVLVEEPPLGLVPG----------VSIRGLKKHF 813

  Fly   119 NRGSKEILHNVCGKFPGSQLIAIMGPSGAGKSTLLDALSG-FKTTGVDGSILLNGRRRDLPSFRR 182
            ....:..|..:...|....:.|.:|.:||||:|.|..||| |..:....|||.:..:.::.:.|.
Mouse   814 RGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSASILGHDVQTNMAAIRP 878

  Fly   183 MSCYITQDDRLQPLLTVNENMHIAADLK-LGQTVSYEEKESRIEDILLLLGLYNHDQTLTMRLSG 246
            ......|.:.|..:|||.|::.....|| :.......|:|..|.|:    ||.....|.|..|||
Mouse   879 HLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAMGPERERLIRDV----GLTLKRDTQTRHLSG 939

  Fly   247 GQKKRLSIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRT-IICTIHQPTAKLFQI 310
            |.:::||:|:..:....|:.:||||.|:|.:|...:.|||.|. .:||| |:.|.|...|:|  :
Mouse   940 GMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKY-REGRTLILSTHHLDEAEL--L 1001

  Fly   311 FDQVYVLSAGNCVYQGSTQKLVPFLQSVDLPCPMY---HNPADYIIELACGEYGYDKVDTLKLAT 372
            .|:|.:::.|:....||               |::   |        |.||.|       |.|..
Mouse  1002 GDRVAMVAGGSLCCCGS---------------PLFLRRH--------LGCGYY-------LTLVK 1036

  Fly   373 ENGSCLT 379
            .:.|.:|
Mouse  1037 SSQSLVT 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	80/290 (28%)
		ABCG_EPDR	102..326	CDD:213180	67/227 (30%)
		ABC2_membrane	420..623	CDD:279410
Abca7	NP_001334010.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1042..1088		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1172..1192
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2126..2167
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000