DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and wht-3

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_497825.2	Gene:	wht-3 / 175528	WormBaseID:	WBGene00007631	Length:	614	Species:	Caenorhabditis elegans

Alignment Length:	651	Identity:	159/651 - (24%)
Similarity:	291/651 - (44%)	Gaps:	72/651 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PSKQPPLEPVVEEE------VHFDTDALNNLPAREPVDMEFKELSL-TVKLGFNRGSKEILHNVC 130
            |:|. |.:.:.|.:      ...||.:........|:.:.::.:.: |.|..|::..|::|:.|.
Worm     2 PTKM-PFDLLAERKRWNAGYESIDTSSQKLTEVVTPITVTWENIEVKTRKKLFSKKQKQLLNRVS 65

  Fly   131 GKFPGSQLIAIMGPSGAGKSTLLDALSGFKTTGVD--GSILLNGRRRDLPSFRRMSCYITQDDRL 193
            |.....:::|:||.|||||:||::.|......|::  |::.:||.:.. .....:|.:..|.:..
Worm    66 GIAKPGEMVALMGASGAGKTTLMNVLMCRNMKGLEKNGTVKVNGTKIG-KEISLISGFAQQQEIF 129

  Fly   194 QPLLTVNENMHIAADLKLGQTVSYEEKESRIEDILLLLGLYN------HDQTLTMRLSGGQKKRL 252
            .|.|||:|.:.|.|.|::  ..:...:..|:::|:.:|.|.|      ....|...:|||:.:||
Worm   130 IPTLTVDEYLMIQARLRM--KANKHTRRERVDEIIEMLRLQNCRDLKIGTPGLVKGISGGEARRL 192

  Fly   253 SIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTAKLFQIFDQVYVL 317
            :.|.||::||:::|.||||:||||.....|:::||.|.:.|||:   ||||||:||..||::..|
Worm   193 TFACELLSNPSLLFADEPTSGLDSFMAASVVQILKNLANSGRTL---IHQPTAELFFQFDKIIFL 254

  Fly   318 SAGNCVYQGSTQKLVPFLQSVDLPCPMYHNPADYIIELACGEYGYDKVDTL-----KLATENGSC 377
            |.|...:.|:..:.|.|......|.|...||.::|         ..|:..:     |.....|..
Worm   255 SMGKTAFMGTPHESVKFFADCGHPIPKLFNPPEWI---------QSKLSVIPNNETKSRETIGKI 310

  Fly   378 LTWF-----HNPSAVLRAEVLMRKYPIPKKTKSRSLEDTSYSNQCSVLLRRGFIKAKRDTTMTHL 437
            :.::     |..|.|....:...:.|       ..:|:..:..:...||:|..:...|......:
Worm   311 IEFYEKSIIHQKSIVEIRVIATTELP-------PYIENPGFFAETGALLKRACLDVIRSPAQMRM 368

  Fly   438 RIGVNIAVAALFGAMYDHTGREGSRVLDNYNLLFAILMHHSMTTMMLTVLTF-PMDISILIKEHF 501
            ::...:.:....|::|.....:...|.:..:.|:.::...:.:| |..::|| ..::.::.:|:.
Worm   369 KLIQKVVMGLFIGSLYWQQPLDPRGVRNTNSALYFLIAELTFST-MFGIMTFMEHELPLIAREYH 432

  Fly   502 NRWYSLKAYYTAMTLVDLPISIISCFFFTVIVYLWSYQPMEWIRFFMFFSISLLTVFVGHSFGLM 566
            :..:.:.:||.:..|..||:..|......||.|........|.:......||:|......|.||.
Worm   433 DGLFYVISYYISRFLSYLPLFTIDGALMIVISYWMIGLNSTWQQVAKSILISVLVEQSATSCGLF 497

  Fly   567 IGAWFDVVNGTFLAPVLTIP----MMMFAGFGVTLRDLPSYLRWGSHISYLRYGLEGFI----SA 623
            :...|:.   |.||....:|    ..:.:|......:.|.|:||....|:.|||.||.:    |.
Worm   498 LACLFET---TSLAIAFAVPASGLFALLSGLYGNTNNFPVYIRWMQWTSWCRYGFEGLVVNQWSQ 559

  Fly   624 IYGLDRGTLACEEAPYCHYRYPKKFLEEITMRGDQFWNDVIALGVMILVFRFVSYVVLKAKIKSI 688
            :           :.|.....|.:..|::.:...|.:..|||.|..:::.|....|:.|..:|:..
Worm   560 V-----------DNPKWDPFYRELILKQFSFNKDNYQLDVIGLCSIVIFFYLAGYIALFIRIRLS 613

  Fly   689 R 689
            |
Worm   614 R 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	152/619 (25%)
		ABCG_EPDR	102..326	CDD:213180	78/232 (34%)
		ABC2_membrane	420..623	CDD:279410	45/211 (21%)
wht-3	NP_497825.2	ABCG_EPDR	36..263	CDD:213180	78/232 (34%)
		3a01204	37..614	CDD:273361	151/613 (25%)
		ABC2_membrane	351..555	CDD:279410	45/207 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720