DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and Abcg8

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_569098.2	Gene:	Abcg8 / 155192	RGDID:	620300	Length:	672	Species:	Rattus norvegicus

Alignment Length:	607	Identity:	157/607 - (25%)
Similarity:	271/607 - (44%)	Gaps:	101/607 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 NNLPARE---PVDME-----FKELSLTVKLGF-NRGSKEI----LHNVCGKFPGSQLIAIMGPSG 146
            |.|..|:   .|||.     |::|: ..||.: :|||::.    :.|:..|....|::||:|.:|
  Rat    45 NTLEVRDLTYQVDMASQVPWFEQLA-QFKLPWRSRGSQDSWDLGIRNLSFKVRSGQMLAIIGSAG 108

  Fly   147 AGKSTLLDALSGFKTTG--VDGSILLNGRRRDLPSFRRMSCYITQDDRLQPLLTVNENMHIAADL 209
            .|::||||.::|....|  ..|.|.:||:.......::...::.|.|:|.|.|||.|.:...|.:
  Rat   109 CGRATLLDVITGRDHGGKMKSGQIWINGQPSTPQLIQKCVAHVRQQDQLLPNLTVRETLTFIAQM 173

  Fly   210 KLGQTVSYEEKESRIEDILLLLGL-----YNHDQTLTMRLSGGQKKRLSIAMELINNPTVMFLDE 269
            :|.:|.|..:::.|:||::..|.|     .....|....:|||:::|:||.::|:.||.::.|||
  Rat   174 RLPKTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDE 238

  Fly   270 PTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTAKLFQIFDQVYVLSAGNCVYQGSTQKLVPF 334
            ||:||||.:...::..|.:|....|.::.::|||.:.:|::||.|.::::|..:|.|..|.:|.:
  Rat   239 PTSGLDSFTAHNLVRTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGVAQHMVQY 303

  Fly   335 LQSVDLPCPMYHNPADYIIELACGEYGYDKVDTLKLATENGSCLTWFHNPSAVLRAEVLMRKY-- 397
            ..|:..|||.|.||||:.::|.       .:|......|..:.      ..|.|.|.:.:.|.
  Rat   304 FTSIGYPCPRYSNPADFYVDLT-------SIDRRSKEQEVATM------EKARLLAALFLEKVQG 355

  Fly   398 --PIPKKTKSRSLEDTSYS---------------------NQCSVLLRRGFIKAKRDTTMTHLRI 439
              ....|.:::||:..:|:                     .|.:.|:||......||.....:..
  Rat   356 FDDFLWKAEAKSLDTGTYAVSQTLTQDTNCGTAAELPGMIQQFTTLIRRQISNDFRDLPTLFIHG 420

  Fly   440 GVNIAVAALFGAMYDHTGREGSRVLDNYNLLFAILMHHSMTTMMLTVLTFPMDISILIKEHFNR- 503
            .....::.:.|.:|.....:....:|...|||          |:..::.|.:.:.::.|.|..|
  Rat   421 AEACLMSLIIGFLYYGHADKPLSFMDMAALLF----------MIGALIPFNVILDVVSKCHSERS 475

  Fly   504 --WYSLK-------AYYTAMTLVDLPISIISCFFFTVIVYLWSYQPMEWIR--------FFMFFS 551
              :|.|:       .|:.|..|.:||   ..|.:  ||:|   ..|:.|:.        |.:.|.
  Rat   476 LLYYELEDGLYTAGPYFFAKVLGELP---EHCAY--VIIY---GMPIYWLTNLRPGPELFLLHFM 532

  Fly   552 ISLLTVFVGHSFGLMIGAWFDVVN-GTFLAPVLTIPMMMFAGFGVTLRDLPSYLRWGSHISYLRY 615
            :..|.||...:..|...|.....: .:|....|.....:.|||.:.|.:|.....|.|.:|:||:
  Rat   533 LLWLVVFCCRTMALAASAMLPTFHMSSFCCNALYNSFYLTAGFMINLNNLWIVPAWISKMSFLRW 597

  Fly   616 GLEG-----FISAIYGLDRGTL 632
            ...|     |...||....|.|
  Rat   598 CFSGLMQIQFNGHIYTTQIGNL 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	156/605 (26%)
		ABCG_EPDR	102..326	CDD:213180	76/240 (32%)
		ABC2_membrane	420..623	CDD:279410	50/226 (22%)
Abcg8	NP_569098.2	ABCG_White	60..295	CDD:213201	73/235 (31%)
		3a01204	88..662	CDD:273361	144/563 (26%)
		ABC2_membrane	401..605	CDD:279410	49/221 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820