DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5853 and abcg8

DIOPT Version :9

Sequence 1:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster
Sequence 2:	NP_001108041.2	Gene:	abcg8 / 100136850	ZFINID:	ZDB-GENE-050517-41	Length:	684	Species:	Danio rerio

Alignment Length:	681	Identity:	175/681 - (25%)
Similarity:	300/681 - (44%)	Gaps:	152/681 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 VHFDTDALNNLPARE-------PVDME------FKELSLTVKLGFNRGSKEILHNVCGKFPGSQL 138
            ::::.|....:|..|       |.:|.      .|:|:|.|..|                   |:
Zfish    61 LNYEVDTAAQIPWYEKLSEFKMPWEMHSNKQTVIKDLNLHVHSG-------------------QM 106

  Fly   139 IAIMGPSGAGKSTLLDALSGFKTTGV--DGSILLNGRRRDLPSFRRMSCYITQDDRLQPLLTVNE 201
            :|::|.||.||::|||.::.....|.  .|.||:||:.......::...::.|||||.|.|||.|
Zfish   107 LAVIGSSGCGKTSLLDIITCRDEGGSMNSGEILINGKPSTRSLVKKSIAHVRQDDRLLPHLTVRE 171

  Fly   202 NMHIAADLKLGQTVSYEEKESRIEDILLLLGLYNHDQT-----LTMRLSGGQKKRLSIAMELINN 261
            .:...|.|:|....|.::::.|::|::..|.|.....|     ....:|||:::|:|||::|:.|
Zfish   172 TLAFVAKLRLPANFSQKQRDQRVDDVIAELRLRQCAHTRVGNEYVRGVSGGERRRVSIAVQLLWN 236

  Fly   262 PTVMFLDEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTAKLFQIFDQVYVLSAGNCVYQG 326
            |.::.|||||:||||.:...::..|.:|....|.::.::|||.:.:||:||.|.:||:|:.||.|
Zfish   237 PGILILDEPTSGLDSFTAHNLVITLYRLARGNRLVLLSVHQPRSDIFQLFDLVVLLSSGSAVYCG 301

  Fly   327 STQKLVPFLQSVDLPCPMYHNPADYIIELACGEYGYDKVDTLKLATENGSCLTWFHNPSAVLRAE 391
            ..:.:|.:..::..|||.|.||:||.::|.       .:|. :...:...||    ..:::|.|:
Zfish   302 QAKDMVSYFTTLGYPCPRYCNPSDYYVDLI-------SIDR-RTPEKEAQCL----EKASMLAAQ 354

  Fly   392 VLMR----------------------KYPIPKKTKSRSLEDTSYS--------NQCSVLLRRGFI 426
            .|.:                      :..:|..:...|:...|..        :|.:.|:||...
Zfish   355 FLEKVKNNEDFMWKSEVCGPPALEAPQSSVPSVSMKESVITVSKQKDQLPGKVHQFTTLIRRQVF 419

  Fly   427 KAKRD--TTMTHLRIGVN-IAVAALFGAMYDHTGREGSRVLDNYNLLFAILMHHSMTTMMLTVLT 488
            ...||  |.:.|   |:. :.::.|.|.:|.....||..:.|...||:           |:..||
Zfish   420 NDYRDLVTLVVH---GLEALLMSLLIGFLYFGCTEEGLSIQDTVALLY-----------MIGALT 470

  Fly   489 -FPMDISILIKEHFNR----------WYSLKAYYTAMTLVDLPISIISCFFFTVIVYLWSYQPME 542
             |.:.:.::.|.|..|          .||:..|:.|..|.:||   ..|.|  .:||   ..|:.
Zfish   471 PFAVVLDVIAKCHSERAMLYHELEDGMYSVTPYFFAKVLGELP---EHCAF--TLVY---GVPIY 527

  Fly   543 WI--------RFFMFFSISLLTVFVGHSFGLMIGAWFDVV-NGTFLAPVLTIPMMMFAGFGVTLR 598
            |:        ||.:.|.:..|||:...|..|.:.|....: ..:|:...|.....:.|||.::|.
Zfish   528 WLAGLNVAPDRFLLNFLLVWLTVYCSRSMALFVAAALPTLQTSSFMGNALFTVFYLTAGFVISLE 592

  Fly   599 DLPSYLRWGSHISYLRYGLEGFISAIYGLDRGTLACEEAPYCHYRYP------------KKFLEE 651
            ::.....|.|:||::|:|.||.:...:   |||           |.|            .|.:|.
Zfish   593 NMWMVASWFSYISFMRWGFEGMLQVQF---RGT-----------RIPITIGNLTVEFDGIKVVEM 643

  Fly   652 ITMRGDQFWNDVIALGVMILVFRFVSYVVLK 682
            :.|.....::..:.|..:.|||..:.|:.||
Zfish   644 MKMNQYPLFSCYLVLIAVSLVFILLYYLSLK 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	174/671 (26%)
		ABCG_EPDR	102..326	CDD:213180	77/236 (33%)
		ABC2_membrane	420..623	CDD:279410	59/225 (26%)
abcg8	NP_001108041.2	3a01204	47..674	CDD:273361	173/679 (25%)
		ABCG_White	72..301	CDD:213201	79/247 (32%)
		ABC2_membrane	413..617	CDD:279410	59/225 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820