Protein Alignment CG42366 and CDKL1

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_004187.3
• Gene: CDKL1 / 8814
• HGNCID: 1781
• Length: 357
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 122/323 - (37%)
• Similarity: 181/323 - (56%)
• Gaps: 26/323 - (8%)

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEE-----AMNLREVKSLKKLSHP 60
            |.:|..:.::|:|:||.|...:.:|||:.||||    |:...|:     .:.|||::.||:|.||
Human     1 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIK----KFLESEDDPVIKKIALREIRMLKQLKHP 61

  Fly    61 NIVKLKEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRD 125
            |:|.|.||.|....|:.||||....:...:......:||..:|||.:|.|..:.|.|:|...|||
Human    62 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRD 126

  Fly   126 LKPENLLCSGPDLIKIADFGLAREIRSRPP--FTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGC 188
            :||||:|.:...:||:.|||.|| :.:.|.  :||||:|||||:||:|:..|.||..:|:||:||
Human   127 VKPENILITKHSVIKLCDFGFAR-LLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGC 190

  Fly   189 IMAELYTFRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHF----RYPDCIKV-PLSS 248
            :.|||.:..||:||.|:||||:.|...||    |..|...::.|...:    :.||...: ||..
Human   191 VFAELLSGVPLWPGKSDVDQLYLIRKTLG----DLIPRHQQVFSTNQYFSGVKIPDPEDMEPLEL 251

  Fly   249 VVSRCSQNGLDLLEDMLAYDPDKRPTAQQSLKYPYFHALKRISPTA-----ATKANVRLNSKY 306
            .....|...|.||:..|..||.:|.|.:|.|.:|||..::.|...|     .|:..:|.:.|:
Human   252 KFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKH 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	114/291 (39%)
CDKL1	NP_004187.3	STKc_CDKL1_4	2..287	CDD:270837	114/293 (39%)
		[NKR]KIAxRE	45..51		1/5 (20%)