Protein Alignment CG42366 and CDK13

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: XP_016868239.1
• Gene: CDK13 / 8621
• HGNCID: 1733
• Length: 1542
• Species: Homo sapiens
• Alignment Length: 778
• Identity: 183/778 - (23%)
• Similarity: 294/778 - (37%)
• Gaps: 212/778 - (27%)

  Fly    10 LGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAM---NLREVKSLKKLSHPNIVKLKEVI-- 69
            :|:||||.|...:.|||||.||:|:::..  :.:|..   .:||:|.|::|:|.:|:.:||::
Human   711 IGEGTYGQVYKARDKDTGEMVALKKVRLD--NEKEGFPITAIREIKILRQLTHQSIINMKEIVTD 773

  Fly    70 --------RENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDL 126
                    ::....|.|||||..:|..:::....|..|..:||.:.|::.||.:.|:..|.|||:
Human   774 KEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDI 838

  Fly   127 KPENLLCSGPDLIKIADFGLAREIRSRP--------------------------------PFTDY 159
            |..|:|.:....||:|||||||...|..                                |:|:.
Human   839 KCSNILLNNRGQIKLADFGLARLYSSEESAWLMLIWEKVIFIWRILLMQMSAGSFGDSSRPYTNK 903

  Fly   160 VSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAELYTFRPLFPGSSEVDQLFKICSVLGTPDKDDW 224
            |.|.|||.||:||....|...||:|:.|||:.||:|.:|:|..:.|:.||..|..:.|:|....|
Human   904 VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVW 968

  Fly   225 PDGYRLASMIHFRYPDCIKVPLSSVVSRCSQ--------------NGLDLLEDMLAYDPDKRPTA 275
                          ||.||:|..:.:....|              ..|||.:.|||.||.||.||
Human   969 --------------PDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTA 1019

  Fly   276 QQSLKYPYFHALKRISPTAATKANVRLNSKYAASNGHPVQSVSNNVLPVQEKLQAVTELLHQTNN 340
            :|:|:..:   |:.:.|:.....::.|     ..:.|.:.|....    ::|...:|:.: .|..
Human  1020 EQALQCEF---LRDVEPSKMPPPDLPL-----WQDCHELWSKKRR----RQKQMGMTDDV-STIK 1071

  Fly   341 NMNSHSNLGKNNNLAPKNGGVPRKYQPK---LSFLTTSEMGAGSHADSSSLV-------GGATVD 395
            ......:||.:::......||....|.|   .|.:...:.|.|.|.:.|.|.       ...:|:
Human  1072 APRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPVKTGPGQHLNHSELAILLNLLQSKTSVN 1136

  Fly   396 GVPVPQHQNGGESINDIYLNRNISQ---LFGLPAG-------------PQH---------QQQQQ 435
            .....|       :.:|.:|....|   ...||||             ||.         |...|
Human  1137 MADFVQ-------VLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGGIQPSSQ 1194

  Fly   436 VHHPNVSFSTTSSRNAGAIYVNGSHLSYDTANMNAKNNAKFVVGASNGGYY-------------V 487
            ...|.|......:....|..|..:.|   .....:|.....:....||..:             .
Human  1195 TIQPKVETDAAQAAVQSAFAVLLTQL---IKAQQSKQKDVLLEERENGSGHEASLQLRPPPEPST 1256

  Fly   488 PVA---------------------RPSLLGPDAKVYNVFSKVSASQAPPSLIVRQPQLQPEVAPA 531
            ||:                     ||.:|.||             |.||     :|...|.|...
Human  1257 PVSGQDDLIQHQDMRILELTPEPDRPRILPPD-------------QRPP-----EPPEPPPVTEE 1303

  Fly   532 PMRLSGRSR----AAAAVQDPKMGALKSDDLDLILGSKLKTSAKRQRNAK--------ANILLED 584
            .:.....::    .::::.||..| :|:..|.|:...:.:...||:....        :....:|
Human  1304 DLDYRTENQHVPTTSSSLTDPHAG-VKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKD 1367

  Fly   585 LFGQLSMDS----DSDGKYPHTVPPTQ----------QAKSGKTSTGGHGAGARERDLFGESY 633
            .||..|..|    .:||....:.||.:          |:....::...|..|..:...|.||:
Human  1368 NFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESF 1430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	106/332 (32%)
CDK13	XP_016868239.1	STKc_CDK12	697..1028	CDD:270847	106/335 (32%)