DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42366 and KDX1

DIOPT Version :9

Sequence 1:	NP_723501.2	Gene:	CG42366 / 34319	FlyBaseID:	FBgn0259712	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_012761.1	Gene:	KDX1 / 853696	SGDID:	S000001644	Length:	433	Species:	Saccharomyces cerevisiae

Alignment Length:	432	Identity:	115/432 - (26%)
Similarity:	200/432 - (46%)	Gaps:	71/432 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRYITLT-QLGDGTYGTVVLGQRKDTGEK--VAIKRMKRKYYSWEEA-MNLREVKSLKKL-SHP 60
            :|::..|| ::|.|::..:......::.|:  |||:::...:.:.... ..|||:|.|:.| .||
Yeast    19 LNKHFHLTGKIGRGSHSLICSSTYTESNEETHVAIRKIPNAFGNKLSCKRTLRELKLLRHLRGHP 83

  Fly    61 NIVKLKE---VIRENDTL---YFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRH 119
            |||.|.:   |...|..|   |...|.|:.:|.|:|:. :..|.:...:|.::|:|..|.::|..
Yeast    84 NIVWLFDTDIVFYPNGALNGVYLYEELMECDLSQIIRS-EQRLEDAHFQSFIYQILCALKYIHSA 147

  Fly   120 GFFHRDLKPENLLCSGPDLIKIADFGLAREIRSRPPFTD-----YVSTRWYRAPEVLLHSTNYGS 179
            ...|.||||:|||.:....:||.:|||:..........|     |:::.||:|||:||:......
Yeast   148 NVLHCDLKPKNLLVNSDCQLKICNFGLSCSYSENHKVNDGFIKGYITSIWYKAPEILLNYQECTK 212

  Fly   180 TIDLWAMGCIMAELYTFRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCI-- 242
            .:|:|:.|||:|||...:|:|.|...||.|..|..:||||.::...:   :||...:.|   |
Yeast   213 AVDIWSTGCILAELLGRKPMFEGKDYVDHLNHILQILGTPPEETLQE---IASQKVYNY---IFQ 271

  Fly   243 --KVP---LSSVVSRCSQNGLDLLEDMLAYDPDKRPTAQQSLKYPYFHALKRISPTAATKANVRL 302
              .:|   ..|::...:...|:||:.||.:||.||.|.:.:|::||......|....:.:...|.
Yeast   272 FGNIPGRSFESILPGANPEALELLKKMLEFDPKKRITVEDALEHPYLSMWHDIDEEFSCQKTFRF 336

  Fly   303 NSKYAAS-------------------NGHPVQSVS-NNVLPVQEKLQAVTELLHQTNNNMNSHSN 347
            ..::..|                   ..||:...| ::.|.:::.:......:|.:...:.|:|
Yeast   337 EFEHIESMAELGNEVIKEVFDFRKVVRKHPISGDSPSSSLSLEDAIPQEVVQVHPSRKVLPSYS- 400

  Fly   348 LGKNNNLAPKNGGVPR-KYQPKLSFLTTSE-----MGAGSHA 383
                          |. .|..:|..|||::     ||..|::
Yeast   401 --------------PEFSYVSQLPSLTTTQPYQNLMGISSNS 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	94/302 (31%)
CG42366	NP_723501.2	S_TKc	4..284	CDD:214567	94/302 (31%)
KDX1	NP_012761.1	STKc_MPK1	22..355	CDD:173750	98/339 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930