Protein Alignment CG42366 and Cilk1

DIOPT Version :9

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_620241.1
• Gene: Cilk1 / 84411
• RGDID: 71050
• Length: 629
• Species: Rattus norvegicus
• Alignment Length: 626
• Identity: 262/626 - (41%)
• Similarity: 353/626 - (56%)
• Gaps: 112/626 - (17%)

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKLSHPNIVKL 65
            ||||.|:.||||||||:|:||:..::||.:|||:||||:|||||.||||||||||||:|.|||||
  Rat     1 MNRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANIVKL 65

  Fly    66 KEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPEN 130
            ||||||||.|||:||||||||||:||:|:...||..:::|::|:|.||||:|:||||||||||||
  Rat    66 KEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPEN 130

  Fly   131 LLCSGPDLIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAELYT 195
            |||.||:|:||||||||||||||||:||||||||||||||||.||||.|.||:||:||||||:||
  Rat   131 LLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYT 195

  Fly   196 FRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVPLSSVVSRCSQNGLDL 260
            .||||||:||:|.:||||.|||||.|.|||:||:|:|.::|.:|.||...|.:::...|...:.|
  Rat   196 LRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFIWPQCIPNNLKTLIPNASSEAIQL 260

  Fly   261 LEDMLAYDPDKRPTAQQSLKYPYF---HAL------------------------KRISPT-AATK 297
            |.|:|.:||.|||||.|:|:||||   |.|                        |...|. |.||
  Rat   261 LRDLLQWDPKKRPTASQALRYPYFQIGHPLGISTQDSGKPQKDVQDKTGPPPYVKPAPPAQAPTK 325

  Fly   298 ANVRLNSK-YAASNGHPVQSVSNNVLPVQEKLQAVTELLHQTNNNMNS------HSNLGKNNNLA 355
            |:..::|: ..||..|     .:.|.|.:.:.....:|.|......|.      |     |.||.
  Rat   326 AHTLISSRPNQASQPH-----QHFVYPYKGEASRTEQLSHVQEGQPNPPFFPSLH-----NKNLP 380

  Fly   356 P--------KNGGVPRKYQPKLSFLTTSEMGAGSHADSSSLVGGATVDGVPVPQHQNGG------ 406
            |        |:|.:..|.:.:...::.|..|:...||.:.|...:::..:.|...:...
  Rat   381 PKILAGLEQKSGDMKPKSRRRWGLISRSTKGSDDWADLADLDFSSSLTRIDVKNKKRQSDDPLCR 445

  Fly   407 -ESINDIYLNRNI-----------SQLFGLP----AGPQHQQQQQVHHPNVSFSTTSSRNAGAIY 455
             ||:.|:..:..:           ||....|    ...||..:...:.|.::.......|.|..:
  Rat   446 FESVLDLKPSEPVGTGTSVSTQASSQRRDTPTLQSTAKQHYLKHSRYLPGINIRNGVLPNPGKDF 510

  Fly   456 VNGSHLSYDTANMNAKNNAKFVV-----------GASNG--GYYVP---------VARPSLLGPD 498
            :..|  |:.::.::.|::....|           .:|.|  |.|:|         |.:...|.|.
  Rat   511 LPSS--SWSSSGLSGKSSGTVSVVSKITSVGSGSTSSTGLTGSYIPSFLKKEVGSVMQRVQLAPL 573

  Fly   499 AKVYNVFSKVSA-------------SQAPPSLIVRQPQLQP 526
            |.....:|.:.|             .::.|.||.|.|.:||
  Rat   574 AAPSPGYSSLKAVRPHPGRPFFHTQPRSTPGLIPRPPAVQP 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	193/279 (69%)
		S_TKc	4..284	CDD:214567	193/279 (69%)
Cilk1	NP_620241.1	STKc_MAK_like	4..284	CDD:270824	193/279 (69%)
		S_TKc	4..284	CDD:214567	193/279 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	292..322		2/29 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	454..482		3/27 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	579..629		9/36 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	428	1.000	Domainoid score	I578
eggNOG	1	0.900	-	-		E1_KOG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001823
OrthoInspector	1	1.000	-	-		otm44863
orthoMCL	1	0.900	-	-		OOG6_101384
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1184
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.770