Protein Alignment CG42366 and Cdkl3

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: XP_008772105.1
• Gene: Cdkl3 / 60396
• RGDID: 619874
• Length: 648
• Species: Rattus norvegicus
• Alignment Length: 649
• Identity: 177/649 - (27%)
• Similarity: 269/649 - (41%)
• Gaps: 130/649 - (20%)

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMN---LREVKSLKKLSHPNI 62
            |..|.||.::|:|:||||:..:.||||..||||..   |...|:::|   .||:|.||:..|.|:
  Rat    13 MEMYETLGKVGEGSYGTVMKCKHKDTGRIVAIKIF---YEKPEKSVNKIATREIKFLKQFRHENL 74

  Fly    63 VKLKEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLK 127
            |.|.||.|:...::.|||::...:...::.....|....|:..|||:|..:.::|.:...|||:|
  Rat    75 VNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIK 139

  Fly   128 PENLLCSGPDLIKIADFGLAREIRSRPP---FTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCI 189
            |||:|.|...:.|:.|||.||.:.:  |   :||||:||||||||::|..|.||..:|:||:||:
  Rat   140 PENILVSQSGITKLCDFGFARTLAA--PGDVYTDYVATRWYRAPELVLKDTTYGKPVDIWALGCM 202

  Fly   190 MAELYTFRPLFPGSSEVDQLFKICSVLG--TP------DKDDWPDGYRLASMIH-----FRYPDC 241
            :.|:.|..|..|.||::|.|.||...:|  ||      .|.....|..|..:.|     .:||.
  Rat   203 IIEMATGNPYLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKNARKKYPK- 266

  Fly   242 IKVPLSSVVSRCSQNGLDLLE-----DMLAYD------------PDKRPTAQQSLKYPYFHALKR 289
            :...|:.:|..|.|  :|..|     |:|.:|            |:.|....|..|...|
  Rat   267 LNGLLADIVHACLQ--IDPAERISSTDLLHHDYFTRDGFIEKFIPELRAKLLQEAKVNSF----- 324

  Fly   290 ISPTAATKAN--VRLNSKYAASN----GHPV---QSVSNNVLPVQEKLQAVTEL--------LHQ 337
            |.|....|.|  ||...|...:|    |:|.   :.|..:....:.|::.:...        |.:
  Rat   325 IKPKENFKENEPVRDEKKPVFTNPLLYGNPTLYGKEVDRDKRAKELKVRVIKAKGGKGDVPDLKK 389

  Fly   338 TNNNMNSHSNLGKNNNLAPKNGGVPRKYQPKLSFLTTSEMGAGSHADSSSLVGGATVDGVPVPQH 402
            |.:. ..|...|...:..|.:  :.||  |.:|.||..     .|..::|       |.|....|
  Rat   390 TESE-GEHRQQGTAEDTHPTS--LDRK--PSVSELTNP-----VHPSANS-------DTVKEDPH 437

  Fly   403 QNGGESINDIYLNRNISQLFGLPAGPQHQQQQQVHHPNVSFSTTSSRNAGAIYVNGSHLSYDTAN 467
            ..|...:..|  |...|.|  |.|.|    ...:.|||...:..:.:...:....|..||    |
  Rat   438 SGGCMIMPPI--NLTSSNL--LAANP----SSNLSHPNSRLTERTKKRRTSSQTIGQTLS----N 490

  Fly   468 MNAKNNAKFVVGASNGGYYVPVARPSLLGPDAKVYNVFSKVSASQAPPSLIVRQPQLQPEVAPAP 532
            ...::.....|....|.:.....:...:....|....|||....:      ...|:|       |
  Rat   491 SRQEDTGPTQVQTEKGAFNERTGQNDQIASGNKRKLNFSKCDRKE------FHFPEL-------P 542

  Fly   533 MRLSGRSRAAAAVQDPKMGALKSDDLDLILGSKLKTSAKRQRNAKANILLEDLFGQLSMDSDSD 596
            ..:..:......|:..|:               ||..:|:..:.|...|       |||||:.:
  Rat   543 FTIQAKEMKGMEVKQIKV---------------LKRESKKTDSPKIPTL-------LSMDSNQE 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	111/315 (35%)
Cdkl3	XP_008772105.1	Protein Kinases, catalytic domain	14..298	CDD:473864	107/291 (37%)