Protein Alignment CG42366 and Cilk1

DIOPT Version :9

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_001157252.1
• Gene: Cilk1 / 56542
• MGIID: 1934157
• Length: 629
• Species: Mus musculus
• Alignment Length: 629
• Identity: 261/629 - (41%)
• Similarity: 353/629 - (56%)
• Gaps: 118/629 - (18%)

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKLSHPNIVKL 65
            ||||.|:.||||||||:|:||:..::||.:|||:||||:|||||.||||||||||||:|.|||||
Mouse     1 MNRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANIVKL 65

  Fly    66 KEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPEN 130
            ||||||||.|||:||||||||||:||:|:...||..:::|::|:|.||||:|:||||||||||||
Mouse    66 KEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPEN 130

  Fly   131 LLCSGPDLIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAELYT 195
            |||.||:|:||||||||||||||||:||||||||||||||||.||||.|.||:||:||||||:||
Mouse   131 LLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVYT 195

  Fly   196 FRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVPLSSVVSRCSQNGLDL 260
            .||||||:||:|.:||||.|||||.|.|||:||:|:|.::|.:|.||...|.:::...|...:.|
Mouse   196 LRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPNNLKTLIPNASSEAIQL 260

  Fly   261 LEDMLAYDPDKRPTAQQSLKYPYF---HALKRIS-------------------------PTAATK 297
            |.|:|.:||.|||||.|:|:||||   |.|..||                         ..|..|
Mouse   261 LRDLLQWDPKKRPTASQALRYPYFQIGHPLGIISKDSGKPQREVQDKTGPPPYIKPAPPAQAPAK 325

  Fly   298 ANVRLNSKYAASNGHPVQSVSNNVLPVQEKLQAVTELLHQTNNNMNSHSNLGK----------NN 352
            |...::|:.:.::..|..||.    |.:..:....:|         ||...||          |.
Mouse   326 AYTLISSRPSQASQPPQHSVH----PYKGDVSRTEQL---------SHVQEGKPSPPFFPSLHNK 377

  Fly   353 NLAP--------KNGGVPRKYQPKLSFLTTSEMGAGSHADSSSLVGGATVDGVPVPQHQNGG--- 406
            ||.|        |||.:..|.:.:...::.|..|:...||...|....::..:.|...:...
Mouse   378 NLQPKILASLEQKNGEIKPKSRRRWGLISRSTKGSDDWADLDDLDFSPSLTRIDVKNKKRQSDDT 442

  Fly   407 ----ESINDIYLNRNI-----------SQLFGLP----AGPQHQQQQQVHHPNVSFSTTSSRNAG 452
                ||:.|:..:.::           ||....|    :..||..:...:.|.::.......|.|
Mouse   443 LCRFESVLDLKPSESVGTGTTVSTQASSQRRDTPTLQSSAKQHYLKHSRYLPGINIRNGVLPNPG 507

  Fly   453 AIYVNGSHLSYDTANMNAKNNAKFVV-----------GASNG--GYYVP---------VARPSLL 495
            ..::..:  |:.::.::.|::....|           .:|:|  |.|:|         |.:...|
Mouse   508 KDFLPSN--SWSSSGLSGKSSGTVSVVSKITSVGSGSASSSGLTGSYIPSFLKKEIGSVMQRVQL 570

  Fly   496 GPDAKVYNVFSKVSA-------------SQAPPSLIVRQPQLQP 526
            .|.|.....:|.:.|             .::.|.||.|.|..||
Mouse   571 APLAAPPPGYSSLKAVRPHPGRPFFHTQPRSTPGLIPRPPAAQP 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	193/279 (69%)
		S_TKc	4..284	CDD:214567	193/279 (69%)
Cilk1	NP_001157252.1	STKc_MAK_like	4..284	CDD:270824	193/279 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	292..376		15/96 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..483		3/27 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	581..629		9/34 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	428	1.000	Domainoid score	I598
eggNOG	1	0.900	-	-		E1_KOG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1662
Isobase	1	0.950	-	0	Normalized mean entropy	S1479
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001823
OrthoInspector	1	1.000	-	-		otm42798
orthoMCL	1	0.900	-	-		OOG6_101384
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.770