Protein Alignment CG42366 and MAPK11

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_002742.3
• Gene: MAPK11 / 5600
• HGNCID: 6873
• Length: 364
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 105/290 - (36%)
• Similarity: 161/290 - (55%)
• Gaps: 20/290 - (6%)

  Fly     7 LTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEA-MNLREVKSLKKLSHPNIVKLKEV-- 68
            |..:|.|.||:|.........:|||:|::.|.:.|...| ...||::.||.|.|.|::.|.:|
Human    27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFT 91

  Fly    69 ----IRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPE 129
                |.:...:|.|...|..:|..::|.:  .|.:..::.:::|:|.||.::|..|..||||||.
Human    92 PATSIEDFSEVYLVTTLMGADLNNIVKCQ--ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPS 154

  Fly   130 NLLCSGPDLIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAELY 194
            |:..:....::|.||||||:  :....|.||:||||||||::|:..:|..|:|:|::|||||||.
Human   155 NVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217

  Fly   195 TFRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFR-----YPDCIKVPLSSVVSRCS 254
            ..:.|||||..:|||.:|..|:|||.    |:.....|..|.|     .|...:..|||:....:
Human   218 QGKALFPGSDYIDQLKRIMEVVGTPS----PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN 278

  Fly   255 QNGLDLLEDMLAYDPDKRPTAQQSLKYPYF 284
            ...:|||..||..|.|:|.:|.::|.:.||
Human   279 PLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	103/288 (36%)
MAPK11	NP_002742.3	Protein Kinases, catalytic domain	8..348	CDD:473864	105/290 (36%)
		TXY	180..182		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..331
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..364