Protein Alignment CG42366 and MAPK1

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_002736.3
• Gene: MAPK1 / 5594
• HGNCID: 6871
• Length: 360
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 108/299 - (36%)
• Similarity: 167/299 - (55%)
• Gaps: 28/299 - (9%)

  Fly     3 RYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKLSHPNIVKLKE 67
            ||..|:.:|:|.||.|..........:||||::....:.......|||:|.|.:..|.||:.:.:
Human    24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIND 88

  Fly    68 VIR-----ENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLK 127
            :||     :...:|.|.:.|:.:||:::|.:  ||....:...|:|:|.||.::|.....|||||
Human    89 IIRAPTIEQMKDVYIVQDLMETDLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLK 151

  Fly   128 PENLLCSGPDLIKIADFGLAREIRSRPP------FTDYVSTRWYRAPEVLLHSTNYGSTIDLWAM 186
            |.|||.:....:||.||||||.  :.|.      .|:||:||||||||::|:|..|..:||:|::
Human   152 PSNLLLNTTCDLKICDFGLARV--ADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSV 214

  Fly   187 GCIMAELYTFRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFR-------YPDCIKV 244
            |||:||:.:.||:|||...:|||..|..:||:|.::|      |..:|:.:       .|...||
Human   215 GCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED------LNCIINLKARNYLLSLPHKNKV 273

  Fly   245 PLSSVVSRCSQNGLDLLEDMLAYDPDKRPTAQQSLKYPY 283
            |.:.:........||||:.||.::|.||...:|:|.:||
Human   274 PWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	107/298 (36%)
MAPK1	NP_002736.3	STKc_ERK1_2_like	19..353	CDD:270839	108/299 (36%)
		TXY. /evidence=ECO:0000269|PubMed:18760948	185..187		1/1 (100%)
		Cytoplasmic retention motif. /evidence=ECO:0000269|PubMed:18760948	318..322
		Nuclear translocation motif. /evidence=ECO:0000269|PubMed:18760948	327..333