Protein Alignment CG42366 and Cdkl2

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_058608.1
• Gene: Cdkl2 / 53886
• MGIID: 1858227
• Length: 568
• Species: Mus musculus
• Alignment Length: 657
• Identity: 183/657 - (27%)
• Similarity: 281/657 - (42%)
• Gaps: 158/657 - (24%)

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIK--------RMKRKYYSWEEAMNLREVKSLKKL 57
            |.:|..|..:|:|:||.|:..:.||:|..||||        :|.:|       :.:||:|.||:|
Mouse     1 MEKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKK-------IAMREIKLLKQL 58

  Fly    58 SHPNIVKLKEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFF 122
            .|.|:|.|.||.::....|.|||::...:...:|.....|....::..|||::.|:.|.|.|...
Mouse    59 RHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNII 123

  Fly   123 HRDLKPENLLCSGPDLIKIADFGLAREIRSRPP---FTDYVSTRWYRAPEVLLHSTNYGSTIDLW 184
            |||:||||:|.|...::|:.|||.||.:.:  |   :||||:||||||||:|:....||..:|:|
Mouse   124 HRDIKPENILVSQSGVVKLCDFGFARTLAA--PGEVYTDYVATRWYRAPELLVGDVKYGKAVDIW 186

  Fly   185 AMGCIMAELYTFRPLFPGSSEVDQLFKICSVLGT--PD------KDDWPDGYRL-------ASMI 234
            |:||::.|:...:|||||.|::|||..|.:.||.  |.      |:....|.||       |..:
Mouse   187 AIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEVKDAEAEPL 251

  Fly   235 HFRYPDCIKVPLSSVVSRCSQNGLDLLEDMLAYDPDKRPTAQQSLKYPYFHA---LKRISPTAAT 296
            ..|||   |:| .:|:|        |.:..|..||||||.....|::.:|..   .:|.|.....
Mouse   252 ESRYP---KLP-EAVIS--------LAKKCLHIDPDKRPFCADLLRHDFFQMDGFAERFSQELQL 304

  Fly   297 KANVRLNSKYAASNGHPVQSVSNNVLPVQEKLQAVTELLHQTNNNMNSHSNLGKNNNLAPKNGGV 361
            |.     .|.|.:|..|.:|.:..    :||..|:.|         ...:.:.::.|..||...
Mouse   305 KI-----EKDARNNSLPKKSQNRK----KEKDDALGE---------ERKTLVVQDTNADPKIKD- 350

  Fly   362 PRKYQPKLSFLTTSEMGAGSHADSSSLVGGATVDGVPVPQHQNG-------GESINDIYLNRNIS 419
            .:.::.|.|.:...:|..||.|.:::.:            |.||       ..|:.|. .|.||.
Mouse   351 SKVFKVKGSKIDVEKMEKGSRASNANCL------------HDNGTNHKGLASTSLRDC-SNVNID 402

  Fly   420 QLFGLPAGPQHQQQQQVHHPNVSFSTTSSRNAGAIYVNGSH-LSYDTANMNAKNNA-----KFVV 478
            .                           |||.|......:| ||.....:||....     .:.|
Mouse   403 H---------------------------SRNPGTAIPPLTHNLSAVAPGINAGMGTIPGVQNYRV 440

  Fly   479 GASNGGYYVPVARPSLLGPDAKVYNVFSKVSAS------QAP------PSLIVRQPQLQPEVAPA 531
            ......|..|..:|: ..|.|.:||:....|.|      ||.      |...||.|:|.....|.
Mouse   441 DEKTKKYCNPFVKPN-QPPPAGIYNMNVSTSVSGEKYLLQANKKRKEYPKADVRLPELNYNHLPE 504

  Fly   532 PMRLSGRSRAAAAVQ-------DPKMGALKSDDLDLILGSKLKTSAKRQRNAKANILLEDLFGQL 589
            ...|.|.:|.:..::       :.::.:|.:.||.:       :|....:.|.:         .|
Mouse   505 LRALEGIARNSRLIKKENKCLSESRIPSLAAIDLHV-------SSVASHQGAGS---------PL 553

  Fly   590 SMDSDSD 596
            |.||::|
Mouse   554 SDDSEAD 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	112/305 (37%)
Cdkl2	NP_058608.1	STKc_CDKL2_3	2..289	CDD:270836	112/307 (36%)
		[NKR]KIAxRE	45..51		1/12 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..333		8/36 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	545..568		6/25 (24%)