Protein Alignment CG42366 and CDK14

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_001274064.1
• Gene: CDK14 / 5218
• HGNCID: 8883
• Length: 469
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 126/339 - (37%)
• Similarity: 182/339 - (53%)
• Gaps: 28/339 - (8%)

  Fly     4 YITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKLSHPNIVKLKEV 68
            |..|.:||:|:|.||..|:.|..|:.||:|.::.:.........:||...||.|.|.|||.|.::
Human   135 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDI 199

  Fly    69 IRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPENLLC 133
            |...:||..||||:..:|.|.:......|....:|..|||:|.||:::|:....||||||:|||.
Human   200 IHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLI 264

  Fly   134 SGPDLIKIADFGLAREIRSRP--PFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAELYTF 196
            |....:|:||||||| .:|.|  .:::.|.|.|||.|:|||.||.|.:.:|:|.:|||..|:...
Human   265 SDTGELKLADFGLAR-AKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQG 328

  Fly   197 RPLFPGSSEV-DQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVPLSSVVSRCSQNGL-- 258
            ...|||..:: |||.:|..|||||::|.||.   :.|:.||: |:...: .||...|.:.|.|
Human   329 VAAFPGMKDIQDQLERIFLVLGTPNEDTWPG---VHSLPHFK-PERFTL-YSSKNLRQAWNKLSY 388

  Fly   259 -----DLLEDMLAYDPDKRPTAQQSLKYPYFHAL-KRI-----SPTAATKANVRLNSKYAAS--- 309
                 ||...:|...|..|.:||.:|.:.||..| .|:     ..:..|..||||..:...|
Human   389 VNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRA 453

  Fly   310 ---NGHPVQSVSNN 320
               |....:|:||:
Human   454 FGKNNSYGKSLSNS 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	112/289 (39%)
CDK14	NP_001274064.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..133
		STKc_PFTAIRE1	129..431	CDD:143374	116/301 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..469		5/19 (26%)