Protein Alignment CG42366 and CDK12

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_057591.2
• Gene: CDK12 / 51755
• HGNCID: 24224
• Length: 1490
• Species: Homo sapiens
• Alignment Length: 771
• Identity: 193/771 - (25%)
• Similarity: 312/771 - (40%)
• Gaps: 198/771 - (25%)

  Fly    10 LGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAM---NLREVKSLKKLSHPNIVKLKEVI-- 69
            :|:||||.|...:.|||||.||:|:::..  :.:|..   .:||:|.|::|.|.::|.:||::
Human   733 IGEGTYGQVYKAKDKDTGELVALKKVRLD--NEKEGFPITAIREIKILRQLIHRSVVNMKEIVTD 795

  Fly    70 --------RENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDL 126
                    ::....|.|||||..:|..:::....|..|..:||.:.|::.||.:.|:..|.|||:
Human   796 KQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDI 860

  Fly   127 KPENLLCSGPDLIKIADFGLAREIRSRP--PFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCI 189
            |..|:|.:....||:|||||||...|..  |:|:.|.|.|||.||:||....|...||:|:.|||
Human   861 KCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCI 925

  Fly   190 MAELYTFRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHF-------RYPDCIKVPLS 247
            :.||:|.:|:|..:.|:.||..|..:.|:|....|||..:|.   :|       :|...::...|
Human   926 LGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLP---YFNTMKPKKQYRRRLREEFS 987

  Fly   248 SVVSRCSQNGLDLLEDMLAYDPDKRPTAQQSLKYPYFHALKRISPTAATKANVRLNSKYAA---- 308
            .:.|.    .||||:.||..||.||.||:|:|:..:   ||          :|.| ||.|.
Human   988 FIPSA----ALDLLDHMLTLDPSKRCTAEQTLQSDF---LK----------DVEL-SKMAPPDLP 1034

  Fly   309 --SNGHPVQSVS-----NNVLPVQEKLQAVTELLHQTNNNMNSHSNLGKNNNLAPKNGGVPRKYQ 366
              .:.|.:.|..     .:.:.|:|...:.|.....|:   .:.:...||::.||     |:...
Human  1035 HWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTS---GTSTEPVKNSSPAP-----PQPAP 1091

  Fly   367 PKLSFLTTSEMGAGSHADSSSLVGGATVDGVPVPQHQNGGE---------SINDIYLNRNISQLF 422
            .|:      |.|||   |:..|        ..:.|..|..|         |..|:.:.: ::||.
Human  1092 GKV------ESGAG---DAIGL--------ADITQQLNQSELAVLLNLLQSQTDLSIPQ-MAQLL 1138

  Fly   423 GLPAGPQHQQQQQVHHPNVSFSTTSS--------------------------------------- 448
            .:.:.|:.|||.:..:.::|..|.::
Human  1139 NIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTP 1203

  Fly   449 ---RNAGAIYVNGSHLSYDTANMNAKNNAKFVVGASNGGYYVPVARPSLLGPDAKVYNVFSKVSA 510
               :|..|:.::....:.:.|....:||:.     .|.|...|...|::           .:..|
Human  1204 ADMQNILAVLLSQLMKTQEPAGSLEENNSD-----KNSGPQGPRRTPTM-----------PQEEA 1252

  Fly   511 SQAPPSLIVRQPQLQPEVAPAPMRLSGRSRAAAAVQDPKMGALKSDDLDLILGSKLKTSAKRQRN 575
            :..||.::  .|:.:|...|.|            ...|....|...||         :||.::.|
Human  1253 AACPPHIL--PPEKRPPEPPGP------------PPPPPPPPLVEGDL---------SSAPQELN 1294

  Fly   576 AKANILLEDLFGQLSMDSDSDGKYPH----------TVPPTQQAKSGKT---STGGHGAGARERD 627
            ......|..|..|  .:::..|..||          :..|......|.|   .||.......||:
Human  1295 PAVTAALLQLLSQ--PEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERN 1357

  Fly   628 LFGESYLPRPGLRKKATQSSLEVNNGSHADSLAPNAQKEKPAVASS--FPWDESNR 681
                   ..|.|.:...|:.  |.|.:.:.||:...:........|  ||.|:..|
Human  1358 -------SGPALTESLVQTL--VKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLR 1404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	107/295 (36%)
CDK12	NP_057591.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..703
		STKc_CDK12	719..1020	CDD:270847	107/298 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1047..1098		11/64 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1189		1/27 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1220..1348		31/168 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1441..1460
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1466..1490