Protein Alignment CG42366 and CDK18

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: XP_054192892.1
• Gene: CDK18 / 5129
• HGNCID: 8751
• Length: 574
• Species: Homo sapiens
• Alignment Length: 345
• Identity: 119/345 - (34%)
• Similarity: 178/345 - (51%)
• Gaps: 31/345 - (8%)

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKLSHPNIVKL 65
            :..|:.|.:||:|||.||..|:.|.|...||:|.::.::........:|||..||.|.|.|||.|
Human   239 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTL 303

  Fly    66 KEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPEN 130
            .::|..:.:|..||||:..:|.|.:......:....:|..:||:|.|||:.|.....||||||:|
Human   304 HDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN 368

  Fly   131 LLCSGPDLIKIADFGLAREIRSRP--PFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAEL 193
            ||.:....:|:||||||| .:|.|  .:::.|.|.|||.|:|||.||.|.:.||:|.:|||..|:
Human   369 LLINERGELKLADFGLAR-AKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEM 432

  Fly   194 YTFRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVPLSSVVSRCSQNGL 258
            .|.|||||||:..::|..|..:||||.::.||.....:....:.:|..:..||.:...|...:|:
Human   433 ATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGI 497

  Fly   259 DLLEDML------AYDPDKRPTAQQSLKYPYFHA-------------LKRISPTAATKANVRLNS 304
            .||..:|      |...:::|.:|    .|..||             :...||..:.....|
Human   498 HLLSSLLLVSVLPAGPRERQPKSQ----VPVPHAGPTPQLLWLVCLHVFETSPLYSPPPRPR--- 555

  Fly   305 KYAASNGHPVQSVSNNVLPV 324
              ...:.||::||.....||
Human   556 --GGLHTHPLESVHCEPKPV 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	108/287 (38%)
CDK18	XP_054192892.1	Protein Kinases, catalytic domain	236..498	CDD:473864	101/259 (39%)