Protein Alignment CG42366 and CDKL3

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: XP_011541731.1
• Gene: CDKL3 / 51265
• HGNCID: 15483
• Length: 619
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 174/645 - (26%)
• Similarity: 270/645 - (41%)
• Gaps: 133/645 - (20%)

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMN---LREVKSLKKLSHPNI 62
            |..|.||.::|:|:||||:..:.|:||:.||||..   |...|:::|   :||:|.||:..|.|:
Human     1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIF---YERPEQSVNKIAMREIKFLKQFHHENL 62

  Fly    63 VKLKEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLK 127
            |.|.||.|:...::.|||::...:...::.....|....|:..|||:|..:.::|.:...|||:|
Human    63 VNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIK 127

  Fly   128 PENLLCSGPDLIKIADFGLAREIRSRPP---FTDYVSTRWYRAPEVLLHSTNYGS---------- 179
            |||:|.|...:.|:.|||.||.:.:  |   :||||:||||||||::|..|:||.
Human   128 PENILVSQSGITKLCDFGFARTLAA--PGDIYTDYVATRWYRAPELVLKDTSYGKYVYFGILSAF 190

  Fly   180 --TIDLWAMGCIMAELYTFRPLFPGSSEVDQLFKICSVLG--TP------DKDDWPDGYRLASMI 234
              .:|:||:||::.|:.|..|..|.||::|.|.||...:|  :|      .|.....|..|..:.
Human   191 PRPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQ 255

  Fly   235 H-----FRYPDCIKVPLSSVVSRCSQNGL--DLLEDMLAYDPDKRPTAQQSLKYPYFHA---LKR 289
            |     .:||              ..|||  |::...|..||..|.::...|.:.||..   :::
Human   256 HPKNARKKYP--------------KLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEK 306

  Fly   290 ISPTAATK--ANVRLNSKYAASNGHPVQSVSNNVLPVQEKLQAVTELLHQTNNNMNSHSNLGKNN 352
            ..|....|  ...::||..     .|.:|...|.|...|:....|       |.:.|.|.|||.
Human   307 FMPELKAKLLQEAKVNSLI-----KPKESSKENELRKDERKTVYT-------NTLLSSSVLGKE- 358

  Fly   353 NLAPKNGGVPRKYQPKLSFLTTSEMGAGSHADSSSLVGGATVDGVPVPQHQNGGESINDIYLNRN 417
                    :.::.:||...:...:: .|...|.|.          |..:...||....|  .|.|
Human   359 --------IEKEKKPKEIKVRVIKV-KGGRGDISE----------PKKKEYEGGLGQQD--ANEN 402

  Fly   418 ISQLFGLPAGPQHQQQQQVHHPNVSFSTTSSRNAGAIYVN---GSHLSYDTANMNAKNNAKFVVG 479
            :.     |..|. .:...:..||   ....|.|...:..|   |..::....|:   .|:..:..
Human   403 VH-----PMSPD-TKLVTIEPPN---PINPSTNCNGLKENPHCGGSVTMPPINL---TNSNLMAA 455

  Fly   480 ASNGGYYVPVARPSLLGPDAKVYNVFSKVSASQAPPSLIVRQP---QLQPEVAPAPMRLSGRSRA 541
            ..:...:.|..|   |...||.....|: |..|..|:.....|   |.|.|......| :|.|..
Human   456 NLSSNLFHPSVR---LTERAKKRRTSSQ-SIGQVMPNSRQEDPGPIQSQMEKGIFNER-TGHSDQ 515

  Fly   542 AAAVQDPKMGALKSD-------DLDLILGSK------------LKTSAKRQRNAKANILL 582
            .|.....|:...:||       :|.:.:.||            ||..:|:..::|...||
Human   516 MANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGMEVKQIKMLKRESKKTESSKIPTLL 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	105/312 (34%)
CDKL3	XP_011541731.1	STKc_CDKL2_3	2..298	CDD:270836	105/314 (33%)