DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42366 and MAK

DIOPT Version :9

Sequence 1:	NP_723501.2	Gene:	CG42366 / 34319	FlyBaseID:	FBgn0259712	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001229886.1	Gene:	MAK / 4117	HGNCID:	6816	Length:	648	Species:	Homo sapiens

Alignment Length:	759	Identity:	275/759 - (36%)
Similarity:	388/759 - (51%)	Gaps:	194/759 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKLSHPNIVKL 65
            ||||.|:.||||||||:|::|:..::||.|||||||||:|||:|.||||||||||||:|.|::||
Human     1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKL 65

  Fly    66 KEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPEN 130
            ||||||||.|||:||||||||||::|||:...||..:::|::|:|.||||:|:|||||||:||||
Human    66 KEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPEN 130

  Fly   131 LLCSGPDLIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAELYT 195
            |||.||:|:||||||||||:||:||:||||||||||||||||.|:.|.|.||:||:|.||||||.
Human   131 LLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYM 195

  Fly   196 FRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVPLSSVVSRCSQNGLDL 260
            .||||||:||||::||||.|||||.|.|||:||:|||.::||:|.|:.:.|.:::...|...:.|
Human   196 LRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQL 260

  Fly   261 LEDMLAYDPDKRPTAQQSLKYPYFHALKRISPTAATKANVRLNSKYAASNGHPVQSVSNNVLPVQ 325
            :.:||.:||.|||||.|:||:|||...:.:.|::.     .|.||         ||::..:.|::
Human   261 MTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSN-----HLESK---------QSLNKQLQPLE 311

  Fly   326 EKLQAVTELLHQTNNNMNSHSNLGKNNNLAPKNGGVPRKYQPK-LSFLTTSEMGAGSHADSSSLV 389
            .|...|                                :.:|| |..:....:|.
Human   312 SKPSLV--------------------------------EVEPKPLPDIIDQVVGQ---------- 334

  Fly   390 GGATVDGVPVPQHQNGGESINDIYLNRNISQLFGLPAGPQHQQQQQVHH-------------PNV 441
                      ||.:...:.:..|...:|:|    :...|:.|.|::...             ||.
Human   335 ----------PQPKTSQQPLQPIQPPQNLS----VQQPPKQQSQEKPPQTLFPSIVKNMPTKPNG 385

  Fly   442 SFSTTSSRN--AGAIYVNGSHL----SYDTANMNAKNNAKFVVGASNGGYYVPVARPSLLGPDAK 500
            :.|..|.|.  ...|:.:|...    .||             .|||:.      .:||:
Human   386 TLSHKSGRRRWGQTIFKSGDSWEELEDYD-------------FGASHS------KKPSM------ 425

  Fly   501 VYNVFSKVSASQAPPSLIVRQPQLQPEVAPAPMRLS-GRSRAAAAVQDPKMGALKSDDLDLILGS 564
              .||.:.....:|..|        ||..|:....| |.:::..||.     :||||       |
Human   426 --GVFKEKRKKDSPFRL--------PEPVPSGSNHSTGENKSLPAVT-----SLKSD-------S 468

  Fly   565 KLKTS-AKRQRNAKANILLEDLF-GQLSMDSDSDGKYPHT------------------------- 602
            :|.|: ..:|...|.:..|..:. .::|:.:......|||
Human   469 ELSTAPTSKQYYLKQSRYLPGVNPKKVSLIASGKEINPHTWSNQLFPKSLGPVGAELAFKRSNAE 533

  Fly   603 ---VPPTQQAKSGKT-------STGGHGAGARERDLFGES-YLPRPGLRKKATQSSLEVNNGSHA 656
               :.|.::....:|       ..|..|:.|    .:.:| |:  |...||      ||.:....
Human   534 ESIIKPIEKLSCNETFPEKLEDPQGNLGSYA----TYNQSGYI--PSFLKK------EVQSAGQR 586

  Fly   657 DSLAPNAQKEKPAVASSFPWD-ESNRTEDEKLTAWMVAENGNLI 699
            ..|||     ..|.||.:.|: ::.|.:....|....|:|.|::
Human   587 IHLAP-----LNATASEYTWNTKTGRGQFSGRTYNPTAKNLNIV 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	186/279 (67%)
CG42366	NP_723501.2	S_TKc	4..284	CDD:214567	186/279 (67%)
MAK	NP_001229886.1	STKc_MAK_like	4..284	CDD:270824	186/279 (67%)
MAK	NP_001229886.1	S_TKc	4..284	CDD:214567	186/279 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145608
Domainoid	1	1.000	430	1.000	Domainoid score	I596
eggNOG	1	0.900	-	-		E1_KOG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001823
OrthoInspector	1	1.000	-	-		otm40724
orthoMCL	1	0.900	-	-		OOG6_101384
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.740