Protein Alignment CG42366 and Cdkl2

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_001012035.2
• Gene: Cdkl2 / 305242
• RGDID: 1309625
• Length: 568
• Species: Rattus norvegicus
• Alignment Length: 634
• Identity: 177/634 - (27%)
• Similarity: 270/634 - (42%)
• Gaps: 172/634 - (27%)

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIK--------RMKRKYYSWEEAMNLREVKSLKKL 57
            |.:|..|..:|:|:||.|:..:.||:|..||||        :|.:|       :.:||:|.||:|
  Rat     1 MEKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKK-------IAMREIKLLKQL 58

  Fly    58 SHPNIVKLKEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFF 122
            .|.|:|.|.||.::....|.|||::...:...:|.....|....::..|||::.|:.|.|.|...
  Rat    59 RHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNII 123

  Fly   123 HRDLKPENLLCSGPDLIKIADFGLAREIRSRPP---FTDYVSTRWYRAPEVLLHSTNYGSTIDLW 184
            |||:||||:|.|...::|:.|||.||.:.:  |   :||||:||||||||:|:....||..:|:|
  Rat   124 HRDIKPENILVSQSGVVKLCDFGFARTLAA--PGEVYTDYVATRWYRAPELLVGDVKYGKAVDIW 186

  Fly   185 AMGCIMAELYTFRPLFPGSSEVDQLFKICSVLGT--PD------KDDWPDGYRL-------ASMI 234
            |:||::.|:...:|||||.|::|||..|.:.||.  |.      |:....|.||       |..:
  Rat   187 AIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEIKDIEAEPL 251

  Fly   235 HFRYPDCIKVP--LSSVVSRCSQNGLDLLEDMLAYDPDKRPTAQQSLKYPYFHA---LKRISPTA 294
            ..|||   |:|  :.|:..:|           |..||||||.....|.:.:|..   .:|.|...
  Rat   252 ESRYP---KLPEVVISLAKKC-----------LHIDPDKRPLCADLLHHDFFQMDGFAERFSQEL 302

  Fly   295 ATKANVRLNSKYAASNGHPVQSVSNNVLP------VQEKLQAVTELLHQTNNNMNSHSNLGKNNN 353
            ..|..               :...||.||      .:||..|:.|         ...:.:.::.|
  Rat   303 QLKIE---------------KDARNNSLPKKFQIRKKEKDDALGE---------ERKTLVVQDTN 343

  Fly   354 LAPKNGGVPRKYQPKLSFLTTSEMGAGSHADSSSL-VGGATVDGVPVPQHQNGGESINDIYLNRN 417
            ..||.                        .||..| |.|:.:|   |.:.:.|..:.|...|:.|
  Rat   344 ADPKT------------------------KDSKVLKVKGSKID---VEKTEKGTRASNGSCLHDN 381

  Fly   418 ISQLFGLPAGPQHQQQQQVHHPNVSFSTTSSRNAGAIYVN-----GSHLSYDTANMNAKN---NA 474
                     |..|:          ..|:||.|:...:.::     |:.:...|.|::|..   ||
  Rat   382 ---------GTSHK----------GLSSTSLRDCSNVTIDHPRNPGTAIPPLTHNLSAVAPGINA 427

  Fly   475 KF--VVGASN-------GGYYVPVARPSLLGPDAKVYNVFSKVSAS--------QAP------PS 516
            ..  :.|..|       ..|..|..:||...|.. :||:  .||||        ||.      |.
  Rat   428 AMGTIPGVQNYRVDEKTKKYCNPFVKPSQPSPSG-IYNM--NVSASVSGEKYLLQANKKRKEYPK 489

  Fly   517 LIVRQPQLQPEVAPAPMRLSGRSRAAAAVQ-------DPKMGALKSDDL 558
            :.||.|:|.....|....|.|.:|.:..::       :.::.:|.:.||
  Rat   490 VDVRLPELNYNHLPELRALEGIARNSRLIKKENKCLSESRIPSLAAIDL 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	111/307 (36%)
Cdkl2	NP_001012035.2	STKc_CDKL2_3	2..289	CDD:270836	111/309 (36%)
		[NKR]KIAxRE	45..51		1/12 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..392		7/45 (16%)