DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42366 and dyf-5

DIOPT Version :9

Sequence 1:	NP_723501.2	Gene:	CG42366 / 34319	FlyBaseID:	FBgn0259712	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001129786.2	Gene:	dyf-5 / 187442	WormBaseID:	WBGene00001121	Length:	489	Species:	Caenorhabditis elegans

Alignment Length:	482	Identity:	222/482 - (46%)
Similarity:	310/482 - (64%)	Gaps:	38/482 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKLSHPNIVKLK 66
            :||:...:|||||:|.|:|.::.|||::|||||||:|:|||||||:||||||||||:||||:||:
Worm     9 DRYLMTKRLGDGTFGEVMLAKKIDTGDRVAIKRMKKKFYSWEEAMSLREVKSLKKLNHPNIIKLR 73

  Fly    67 EVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPENL 131
            |||||||.||||||:|:||||:::||||.:.||..:::|::|||.||||||::||||||:||||:
Worm    74 EVIRENDILYFVFEFMQENLYELMKDRDRYFPESVIRNIIYQVLQGLAFMHKNGFFHRDMKPENI 138

  Fly   132 LCSGPDLIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAELYTF 196
            :|:|.:|:|||||||||||||:||:|||||||||||||:||.||:|.|.||:||:||||||||..
Worm   139 MCNGTELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRSTSYNSPIDMWALGCIMAELYIL 203

  Fly   197 RPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVPLSSVVSRCSQNGLDLL 261
            ||||||:||:||||||.|:||||:||:||:||:|||.::||:...:..|:..||:..|:.|:.|:
Worm   204 RPLFPGTSEMDQLFKIISILGTPNKDEWPEGYQLASAMNFRFQQVVATPMEQVVNTISKEGMKLM 268

  Fly   262 EDMLAYDPDKRPTAQQSLKYPYFHALKRI-SPTAATKANVRLNSKYAASNGHPVQSV-------- 317
            .||:.::|:|||.|.|||:|.||...::: :|..:..|...:....|||.....:::
Worm   269 MDMMLWNPEKRPNANQSLRYKYFQVAEKLGAPVVSQPAPGSIRKTSAASVKSDTKAMTAKAAKKD 333

  Fly   318 ---SNNVLPVQEKLQAVTELLHQTNNNMNSHSNLGKNNN--LAP--KNGGVP---------RKYQ 366
               |.||.| |:..:.:...::: |..:|..:...|::|  |.|  .|...|         .||.
Worm   334 YIGSENVSP-QQPAKVIDRHINR-NLPLNKETLFEKSDNKPLGPTKSNEAKPTAKEIYLSKSKYV 396

  Fly   367 PKLSFLTTSEMGAGSHADSSSLVGG--ATVDGVPVPQHQNGGESIND--IYLNRNISQLFGLPAG 427
            |       .::...:|.:......|  .|.........:.|..::..  .|....|........|
Worm   397 P-------GQVSKDTHQNQIMTTNGLTGTTKTTTFSAKKEGRTAVQTRFEYAYGYIPSFGARQTG 454

  Fly   428 PQHQQQQQVHHPNVSFSTTSSRNAGAI 454
            |....|...|..|.|.|.....|.|.:
Worm   455 PTVSNQTNNHSANNSHSPNKMSNTGRV 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	183/279 (66%)
CG42366	NP_723501.2	S_TKc	4..284	CDD:214567	183/279 (66%)
dyf-5	NP_001129786.2	STKc_MAK_like	11..291	CDD:270824	183/279 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158647
Domainoid	1	1.000	417	1.000	Domainoid score	I327
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1479
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001823
OrthoInspector	1	1.000	-	-		oto19549
orthoMCL	1	0.900	-	-		OOG6_101384
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3024
SonicParanoid	1	1.000	-	-		X1184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.820