Protein Alignment CG42366 and CDK9

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_001252.1
• Gene: CDK9 / 1025
• HGNCID: 1780
• Length: 372
• Species: Homo sapiens
• Alignment Length: 372
• Identity: 111/372 - (29%)
• Similarity: 184/372 - (49%)
• Gaps: 57/372 - (15%)

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAM---NLREVKSLKKLSHPNI 62
            :::|..|.::|.||:|.|...:.:.||:|||:|::..:  :.:|..   .|||:|.|:.|.|.|:
Human    16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME--NEKEGFPITALREIKILQLLKHENV 78

  Fly    63 VKLKEVIRE--------NDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRH 119
            |.|.|:.|.        ..::|.||::.:.:|..::.:........|:|.::..:|.||.::||:
Human    79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143

  Fly   120 GFFHRDLKPENLLCSGPDLIKIADFGLAREI----RSRP-PFTDYVSTRWYRAPEVLLHSTNYGS 179
            ...|||:|..|:|.:...::|:|||||||..    .|:| .:|:.|.|.|||.||:||...:||.
Human   144 KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGP 208

  Fly   180 TIDLWAMGCIMAELYTFRPLFPGSSEVDQLFKICSVLGTPDKDDWP--DGYRLASMIHFRYPDCI 242
            .||||..||||||::|..|:..|::|..||..|..:.|:...:.||  |.|.|...:     :.:
Human   209 PIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKL-----ELV 268

  Fly   243 KVPLSSVVSRC-----SQNGLDLLEDMLAYDPDKRPTAQQSLKYPYFHA------LKRISPTAAT 296
            |.....|..|.     ....|||::.:|..||.:|..:..:|.:.:|.:      ||.:..|..|
Human   269 KGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLT 333

  Fly   297 KANVRLNSKYAASNGHPVQSVSNNVLPVQEKLQAVTELLHQTNNNMN 343
                               |:...:.|.:.|...:|:  ..||.:.|
Human   334 -------------------SMFEYLAPPRRKGSQITQ--QSTNQSRN 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	99/302 (33%)
CDK9	NP_001252.1	STKc_CDK9	6..315	CDD:270848	99/305 (32%)
		T-loop	166..191		11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..372		5/19 (26%)