Protein Alignment CG42366 and Cdkl5

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: XP_017457779.1
• Gene: Cdkl5 / 100362725
• RGDID: 2324133
• Length: 1001
• Species: Rattus norvegicus
• Alignment Length: 841
• Identity: 210/841 - (24%)
• Similarity: 350/841 - (41%)
• Gaps: 207/841 - (24%)

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWE-EAMNLREVKSLKKLSHPNIVK 64
            ||::..|..:|:|.||.|:..:.|:|.|.||||:.|....:.| :...|||:|.|:.|...|||:
  Rat    10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVE 74

  Fly    65 LKEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPE 129
            |||..|....||.||||:::|:.:::::....:|..::||.::|::..:.:.|::...|||:|||
  Rat    75 LKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPE 139

  Fly   130 NLLCSGPDLIKIADFGLAREIR--SRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAE 192
            |||.|..|::|:.|||.||.:.  :...:|:||:|||||:||:|| ...||.::|:|::|||:.|
  Rat   140 NLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPYGKSVDMWSVGCILGE 203

  Fly   193 LYTFRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVP----------LS 247
            |...:|||||.||:||||.|..|||....:.....|........|:| .:..|          |:
  Rat   204 LSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFP-AVNHPQSLERRYLGILN 267

  Fly   248 SVVSRCSQNGLDLLEDMLAYDPDKRPTAQQSLKYPYFHALKRI--SPTAATK-----------AN 299
            ||:       |||::::|..||..|...:|.|.:|.|...:.:  ||:.:||           :|
  Rat   268 SVL-------LDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSTKRKPYHVESSTLSN 325

  Fly   300 VRLNSKYAA------SNGHPVQSVSNNVLPVQEKLQAVTELLHQTNNNM---------------- 342
            ...::|..|      ||...:|::|..:...:|.|.|....|   |.|:
  Rat   326 RSQSTKGGALQTHHRSNSKDIQNLSVGLPRAEEGLPANESFL---NGNLAGATLSPMHTKTYQAS 387

  Fly   343 ----NSHSNLGKNN------------------NLAPKNGGVP---------RKYQPKLSFLTTSE 376
                :|..:|..||                  |:.||....|         |..|.:.||:.:|:
  Rat   388 TQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSSTRSQQNRHSFMESSQ 452

  Fly   377 MGAGSHADSSSLVGGATVDGVP----VPQHQNGGESINDIYLNRNISQL---------------- 421
            ..||:...|......:.:|.:|    .|.::...:|...:..::::|.|
  Rat   453 SKAGTLQPSEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETNTSRYF 517

  Fly   422 ------FGLPAGP---QHQQQQQVHHPNVSFSTTSSRNAGAI--------------------YVN 457
                  ...|..|   :|...:.:..|    |..::||.|.:                    :::
  Rat   518 PSSCLDLNSPTSPTPTRHTDTRTLLSP----SGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMD 578

  Fly   458 GSHLSYDTANMNAKNNAKFVVGASNGGYYVPVA---RP-------------------SL-----L 495
            .||    :.:::|.:.: |..|.   ||..|.:   ||                   ||     :
  Rat   579 SSH----SHSLSAPHES-FSYGL---GYTSPFSSQQRPHRHSMYVTRDKVRAKGIDGSLSIGQGM 635

  Fly   496 GPDAKVYNVFSKVSASQAPPSLIVRQPQLQPEVAPAPMRLSGRSRAAAAV-QDP---------KM 550
            ...|....:.|.....|.||.:.|.:|.::............|.::...| .||         :.
  Rat   636 AARANSLQLLSPQPGEQLPPEMTVARPSVKESSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKEN 700

  Fly   551 GALKSDDLDLILGSKLKTSAKRQRNAKANILLEDLFGQLSMDSDSDGKYPHTVPPTQQAKSGKTS 615
            ..|.:|.:...:||..:..:.|..|:.....:......|..||.|...:....|.....||.:..
  Rat   701 RHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSDSSSGTNHSKRQPGFDPWKSPENI 765

  Fly   616 TGGHGAGARERDLFGESYLPRPGLRKKATQSSLEVNNGSHADSLAPNAQKEKPAVASS-FP 675
            :  |....:|::..|  :......:||.||:: :..||            |.|::..| ||
  Rat   766 S--HSDQLKEKEKQG--FFRSMKKKKKKTQTT-DSTNG------------ENPSIKKSLFP 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	110/292 (38%)
Cdkl5	XP_017457779.1	STKc_CDKL5	11..297	CDD:270838	111/294 (38%)