DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TbCMF46 and CG14185

DIOPT Version :9

Sequence 1:	NP_609325.2	Gene:	TbCMF46 / 34318	FlyBaseID:	FBgn0032163	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster

Alignment Length:	280	Identity:	58/280 - (20%)
Similarity:	99/280 - (35%)	Gaps:	84/280 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DAVEETEEEPLRGFLEEI------NCPEPGIID--RQMIETAYLEEGKKGEARRLHQLEPVVYDR 68
            |.....||:.|..|:..:      ..|||.:.:  |::.:...||..::...|       |:...
  Fly    76 DVAIAEEEQHLPAFVHLLPVVLPQQGPEPTLDELLRRVTQRTDLEAVEQVRLR-------VISYT 133

  Fly    69 ITTMRLEFKNILRIDHLWMMPNLTKLCLNCNKIEVIEHLEMLTALKDLNLSFNYITRI------- 126
            ::..||..          .:|.|..|.|:.:         :|::|:||......:||:
  Fly   134 VSLSRLSL----------FLPRLQSLDLSGS---------VLSSLRDLGYGLLQLTRLDISNCGL 179

  Fly   127 ---ENLEKLVKLEKLSLFSNRIRKIENIHTLQNLVILSIGNNLIDTVEGIERLRFVSSLKVLNLE 188
               :....|..:..|....|.|::::.:..|.:|.:|...||.|..:..:..|.....|:.:.|:
  Fly   180 NSFDGTSGLPAIRVLIADGNMIQRVDPLAELVHLRVLKARNNRISELGLLSFLGMCPQLQEVELQ 244

  Fly   189 GNPIAKQPDFPLSLYVIAILPQLNYYEYVFIKTETREEAQKRFYREL--REIEDKQ---EREIQG 248
            |||:.:.|                                  .||.|  |.:...|   .|.:.|
  Fly   245 GNPVCRLP----------------------------------LYRSLLARSVPTLQLLDGRVLNG 275

  Fly   249 LETEAREMAEADRLASSFVE 268
             |....||.||...|||.:|
  Fly   276 -EPAPVEMEEATSPASSDLE 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TbCMF46	NP_609325.2	leucine-rich repeat	69..90	CDD:275378	2/20 (10%)
		LRR_8	89..145	CDD:290566	13/65 (20%)
		LRR_4	89..131	CDD:289563	10/51 (20%)
		leucine-rich repeat	91..112	CDD:275378	4/20 (20%)
		leucine-rich repeat	113..134	CDD:275378	6/30 (20%)
		LRR_8	134..192	CDD:290566	14/57 (25%)
		LRR_4	134..174	CDD:289563	9/39 (23%)
		leucine-rich repeat	135..156	CDD:275378	4/20 (20%)
		leucine-rich repeat	157..181	CDD:275378	6/23 (26%)
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	13/65 (20%)
		leucine-rich repeat	146..168	CDD:275380	7/30 (23%)
		LRR_4	168..209	CDD:289563	6/40 (15%)
		leucine-rich repeat	169..190	CDD:275380	3/20 (15%)
		leucine-rich repeat	191..212	CDD:275380	4/20 (20%)
		leucine-rich repeat	213..237	CDD:275380	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810