Protein Alignment TbCMF46 and LRRC43

DIOPT Version :10

• Sequence 1: NP_609325.2
• Gene: TbCMF46 / 34318
• FlyBaseID: FBgn0032163
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: XP_047284614.1
• Gene: LRRC43 / 254050
• HGNCID: 28562
• Length: 688
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 88/407 - (21%)
• Similarity: 157/407 - (38%)
• Gaps: 107/407 - (26%)

  Fly     2 DEPVSSQPGEDAVEETEEEPLRGFLEEINCPEPGIIDRQMIETAYLEEGKKGEARRLHQLEPVV- 65
            :|.|.| |||:.|     |.|.|.:...:.|. .:::....|.::|        |.|....|:.
Human    70 EEDVVS-PGEETV-----EALLGLVRSRHSPW-ALLNNSNAEDSFL--------RELAIRNPLTI 119

  Fly    66 -----YDRITTMRLEFKNILRID-HLWMMPNLTKLCLNCNKIEVIEHLEMLTALKDLNLSFNYIT 124
                 |....::|:..|.:..:| .|.....|.:|.|:.|:|:.::...:...||.|.|..|.|:
Human   120 TDTFFYSYFRSLRVIDKKVTLVDKDLLKFLKLEELVLSANRIKEVDATNLPPTLKVLELYGNEIS 184

  Fly   125 RIENL--EKLVKLEKLSLFSNR-IRKIENIH------------------------TLQNLVILSI 162
            .:|.|  .....|:.|.|..|: :..:|:::                        :..|||.|.:
Human   185 SMECLCAHPPAGLQHLGLGHNKLLGPLESLYVTANHWLLAPCSPGFLTPRRSCSPSRPNLVSLDL 249

  Fly   163 G-NNLIDTVEGIERLRFVSSLKVLNLEGNPIAKQPDFP----LSLYVIAILPQLNYYEYVFIKTE 222
            | |:|.|....:..||.:..|::|.|:|||:|..|.:.    .||..:.:|..:
Human   250 GFNDLTDLQSMVTSLRTLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDI----------- 303

  Fly   223 TREEAQKRFYRELREIEDKQEREIQGLET--------EAREMAEADRLASSFVEHLDGMQLYDSL 279
            |....:|..:|.|....|...:|.|.:.|        :...:....|....|:.: :....||.:
Human   304 TVSPNEKHLFRGLSLNGDLLAQEAQFVVTIGNIRGVLDTSVLDPEPRPEGPFITY-NYYVTYDFV 367

  Fly   280 WRDDEDGR-----------------ILMLVGAPAQELCEEYSKD-VYELTQQIYRLGLERFGERD 326
              .||:|.                 :.:||....:|:.|:..:| |.|:|:::.       |..:
Human   368 --KDEEGEMNESAGVLAEIVKPSPSLELLVEESPEEVVEDVIEDIVEEVTEEVE-------GSLE 423

  Fly   327 EEIRDFNANLHEGQEEL 343
            .|:.:      .|:.||
Human   424 SEVEE------SGESEL 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TbCMF46	NP_609325.2	PPP1R42	66..>190	CDD:455733	36/152 (24%)
		leucine-rich repeat	69..90	CDD:275378	4/21 (19%)
		leucine-rich repeat	91..112	CDD:275378	5/20 (25%)
		leucine-rich repeat	113..134	CDD:275378	8/22 (36%)
		leucine-rich repeat	135..156	CDD:275378	5/45 (11%)
		leucine-rich repeat	157..181	CDD:275378	9/24 (38%)
		SMC_prok_B	225..>530	CDD:274008	27/145 (19%)
LRRC43	XP_047284614.1	PPP1R42	156..310	CDD:455733	38/164 (23%)
		leucine-rich repeat	173..196	CDD:275378	8/22 (36%)
		leucine-rich repeat	197..243	CDD:275378	5/45 (11%)