DRSC/TRiP Functional Genomics Resources

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Protein Alignment TbCMF46 and LRGUK

DIOPT Version :10

Sequence 1:NP_609325.2 Gene:TbCMF46 / 34318 FlyBaseID:FBgn0032163 Length:566 Species:Drosophila melanogaster
Sequence 2:NP_001352629.1 Gene:LRGUK / 136332 HGNCID:21964 Length:1131 Species:Homo sapiens


Alignment Length:680 Identity:138/680 - (20%)
Similarity:240/680 - (35%) Gaps:206/680 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 GEDAVEETEEEPLRGFLEEINCPEPGIIDRQMIETAYLEEGKKGEARRLHQLEPVVYDRITTMRL 74
            ||...||:.|..:....||.:    |::..:.:..|....|:.|....      .||..:|   |
Human    83 GEAGSEESSESEMLNLEEEFD----GVLREEAVAKALHHLGRSGSGTE------QVYLNLT---L 134

  Fly    75 EFKNILRIDHLWMMPNLTKLCLNCNKIEVIEHLEMLTALKDLNLS-------FNY---------- 122
            ...|::.:..|....:|.||.|:.||||.:..:..:..|.:||.|       ||:          
Human   135 SGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKAD 199

  Fly   123 -----ITRIENLEKLVKLEKLSLFSNRIRKIENIHTLQNLVILSIGNNLIDTVEGIERLRF---- 178
                 |:.|.:|.....|.||.|..|.|.:|..:....||:.||:.||.|.|:.|:.:|..    
Human   200 FSHNQISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLPIKILC 264

  Fly   179 ---------------------------VSS---------LKVLNLEGNPIA--KQPDFPLSLYVI 205
                                       :||         |:|:|||.|.||  ::.::..:|.::
Human   265 LSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPIL 329

  Fly   206 AILPQLN---------YYEYVFIKTETREEAQKRFYRELREIEDKQEREIQGLETEAREMAEADR 261
            .:|..|.         ::..:|:.....|..||:.     ::|:|.. .:...:.....:|..|.
Human   330 RVLNLLENPIQEKSEYWFFVIFMLLRLTELDQKKI-----KVEEKVS-AVNKYDPPPEVVAAQDH 388

  Fly   262 LASSFVEHLDGMQLYDS-LWRDDEDGRILMLVGAP-------AQELCEEYSKDVYELTQQIYRLG 318
            |.......:...:::|| |...|....:|:|.|..       |..||.::|        ..:|.|
Human   389 LTHVVNSVMQPQRIFDSTLPSLDAPYPMLILAGPEACGKRELAHRLCRQFS--------TYFRYG 445

  Fly   319 LERFGERDEEIRDFNANLHEGQEELQAQGQRQIEDFLEYKERIFDEMRLKWRELDQRDDDLEQLQ 383
            .                .|..:.....:|.|  .|:....:.:||||                :.
Human   446 A----------------CHTTRPPYFGEGDR--VDYHFISQDVFDEM----------------VN 476

  Fly   384 AQLDTLTANF--------EDSLNELWESLMAQELHLH-EAVEDSTLKFNRKISDLMSNFVEQAQV 439
            .....||.::        .|::..:....:|..:|:. |.|.  :||:         ::.|...:
Human   477 MGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVR--SLKY---------SYFEPRYI 530

  Fly   440 I-----------FLQLRDLCS----YFADNMTDI---VNQ----FLSTKLARNELNTIPEELKQC 482
            :           :|:.:.|.|    .||.:..|:   :||    :....:..::|:...::|.|.
Human   531 LVVPMNKEKYEGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQL 595

  Fly   483 VDDREAVLQLVE----GMRTTHTSRVDKRED------RLAQRSR-----QFIDDMITNLNNKEVD 532
            :  || .|.|.|    .:.||.......::.      .|....|     |....|..:|:..:: 
Human   596 I--RE-YLGLTEEPAKSLATTAAGAPASKKTVSGVPAHLVPSPRCLAKLQADGQMTEHLSGMQI- 656

  Fly   533 RHRAKILEINSFMEMMTEALANLPGELHQE 562
              .||.||..|......:.||. .||.||:
Human   657 --HAKDLENQSVTPAQNQELAQ-DGETHQK 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TbCMF46NP_609325.2 PPP1R42 66..>190 CDD:455733 46/185 (25%)
leucine-rich repeat 69..90 CDD:275378 4/20 (20%)
leucine-rich repeat 91..112 CDD:275378 8/20 (40%)
leucine-rich repeat 113..134 CDD:275378 9/42 (21%)
leucine-rich repeat 135..156 CDD:275378 7/20 (35%)
leucine-rich repeat 157..181 CDD:275378 9/54 (17%)
SMC_prok_B 225..>530 CDD:274008 62/358 (17%)
LRGUKNP_001352629.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 73..96 5/12 (42%)
LRR 1 129..149 5/22 (23%)
leucine-rich repeat 131..150 CDD:275380 4/21 (19%)
PPP1R42 <132..181 CDD:455733 16/51 (31%)
LRR 2 150..171 8/20 (40%)
leucine-rich repeat 151..172 CDD:275380 8/20 (40%)
LRR 3 172..193 6/20 (30%)
leucine-rich repeat 173..194 CDD:275380 6/20 (30%)
PPP1R42 176..369 CDD:455733 43/197 (22%)
LRR 4 194..215 3/20 (15%)
leucine-rich repeat 195..216 CDD:275380 3/20 (15%)
LRR 5 216..237 7/20 (35%)
leucine-rich repeat 217..238 CDD:275380 7/20 (35%)
LRR 6 238..259 9/20 (45%)
leucine-rich repeat 258..281 CDD:275380 1/22 (5%)
LRR 7 260..280 0/19 (0%)
LRR 8 281..302 2/20 (10%)
leucine-rich repeat 282..300 CDD:275380 2/17 (12%)
LRR 9 303..324 8/20 (40%)
leucine-rich repeat 304..328 CDD:275380 9/23 (39%)
GMPK 416..592 CDD:238026 36/228 (16%)
PHA03247 <784..1126 CDD:223021
Blue background indicates that the domain is not in the aligned region.

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