Protein Alignment TbCMF46 and Lrrc49

DIOPT Version :10

• Sequence 1: NP_609325.2
• Gene: TbCMF46 / 34318
• FlyBaseID: FBgn0032163
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_663591.3
• Gene: Lrrc49 / 102747
• MGIID: 2442689
• Length: 752
• Species: Mus musculus
• Alignment Length: 679
• Identity: 129/679 - (18%)
• Similarity: 252/679 - (37%)
• Gaps: 197/679 - (29%)

  Fly     6 SSQPGEDAVEETEEEPLRGFLEEINCPEPGIIDRQMIETAYLEEGKKGEARRLHQLEPVVYDRIT 70
            ||.|....::.:.||... :.:.:.      ::||.:....:.:|:               :.:.
Mouse   139 SSMPAFPILQRSSEEKTL-YSDRLT------LERQKLTVCPIIDGE---------------EHLR 181

  Fly    71 TMRLEFKNILRIDHLWMMPNLTKLCLNCNKIEVIEHLEMLTALKDLNLSFNYITRIENLEKLVKL 135
            .:..:...|.||.::..:..|..|.|..|:||.|..|..|.:|:.|.|..|.|.:|.|||.|..|
Mouse   182 LLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKNRIKKISNLENLKNL 246

  Fly   136 EKLSLFSNRIRKIENIHTLQNLVILSIGNNL---IDTVEGIE----------RLRFV-------- 179
            :.|.|..|:|.||||::.|.:|.:|::..||   :|.:.|::          ::.||
Mouse   247 DVLDLHGNQITKIENVNHLCDLRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPC 311

  Fly   180 -----------------------SSLKVLNLEGNPIAKQPDFPLSLYVIAILPQLNYYEYVFIKT 221
                                   :||..:..:|||||::     |.|...:|..:.....:.:|.
Mouse   312 LQRLFLSFNNITSFESVSCLAESTSLSDITFDGNPIAQE-----SWYKHTVLQNMMQLRQLDMKR 371

  Fly   222 ETREEAQKRFYRELREIEDKQEREIQGLETEAREMAEADRLASSFVEHLDGMQLYDSL--WRDDE 284
            .|.||.:.......:|.|.|:|...|.|..|.:.:.     .::.....|..|...::  .:|.:
Mouse   372 ITEEERRVASVVAKKEEEKKRESHKQSLLKEKKRLT-----INNVARKWDLQQRVANIASTQDRK 431

  Fly   285 DGRILMLVGAPAQELCEEYSKDVYELTQQIYRL------GLERFGERDEEIRDFNANLHEGQEEL 343
            |..      :|.||.|:....::....::...|      .|:.....:..:.:.:.      |.|
Mouse   432 DSE------SPPQESCQLDGGNISAFPEEAGSLDAGLSSALQGLSVTETHLVEIDG------ETL 484

  Fly   344 QAQGQRQIE-------------------DFLEYKE----------RIFDEMRLKWRELD----QR 375
            ...|...:|                   .|:|:.|          :..:.:.||:||.:    |:
Mouse   485 SLYGSGALECLDRNWSVQTAGMVTTVSFTFIEFDEIVQVLPKLKMKFPNSLHLKFRETNLVMLQQ 549

  Fly   376 DDDLEQLQAQLDTLT--------ANFEDSLNELWE--------SLMAQELHLHEAVEDSTLKFNR 424
            .:.|.||: ::|.||        .||     .||:        ....|:::..|..::..:...|
Mouse   550 FNALAQLR-RVDQLTIDPQGNPVVNF-----TLWKYYVLFRLSHFSMQKINGTEVTQNDMIMAER 608

  Fly   425 K---ISDLMSNFVEQAQVIFL-------QLRDL-----------CSYFADNMTDIVNQFLSTKLA 468
            .   ::.:.|:.:.|.::|.:       |.|.|           |...:|:     .:||.....
Mouse   609 LFGILAHVASSELPQYRMISILGDARKKQFRYLLESKGKKPGIICEETSDS-----KRFLGENTN 668

  Fly   469 RNELNTIP-----EELKQCVDDREAVLQLVEGMRTTHTSRVDKREDRLAQRSRQFIDDMITNLNN 528
            |..||...     |:|::..|.::.....||.: ....:.::.:.:.|.:...|...:::
Mouse   669 RATLNYTTREFYHEKLEEIKDKKKFCRLYVEDL-VKEATAINMKNEALQKLWPQMFIELV----- 727

  Fly   529 KEVDRHRAKILEI---NSFMEMMTEALAN 554
                  |..::||   :|:|::..:.:.:
Mouse   728 ------RDAVIEIRSKDSYMKLCLQQITD 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TbCMF46	NP_609325.2	PPP1R42	66..>190	CDD:455733	42/167 (25%)
		leucine-rich repeat	69..90	CDD:275378	3/20 (15%)
		leucine-rich repeat	91..112	CDD:275378	9/20 (45%)
		leucine-rich repeat	113..134	CDD:275378	10/20 (50%)
		leucine-rich repeat	135..156	CDD:275378	10/20 (50%)
		leucine-rich repeat	157..181	CDD:275378	8/67 (12%)
		SMC_prok_B	225..>530	CDD:274008	64/387 (17%)
Lrrc49	NP_663591.3	leucine-rich repeat	160..177	CDD:275380	2/22 (9%)
		leucine-rich repeat	180..201	CDD:275380	3/20 (15%)
		PPP1R42	183..378	CDD:455733	54/199 (27%)
		leucine-rich repeat	202..223	CDD:275380	9/20 (45%)
		leucine-rich repeat	224..245	CDD:275380	10/20 (50%)
		leucine-rich repeat	246..267	CDD:275380	10/20 (50%)
		leucine-rich repeat	268..289	CDD:275380	6/20 (30%)
		leucine-rich repeat	290..311	CDD:275380	2/20 (10%)
		leucine-rich repeat	312..336	CDD:275380	0/23 (0%)