Protein Alignment CG4592 and HIBCH

DIOPT Version :10

• Sequence 1: NP_609324.2
• Gene: CG4592 / 34317
• FlyBaseID: FBgn0032162
• Length: 287
• Species: Drosophila melanogaster
• Sequence 2: NP_055177.2
• Gene: HIBCH / 26275
• HGNCID: 4908
• Length: 386
• Species: Homo sapiens
• Alignment Length: 315
• Identity: 63/315 - (20%)
• Similarity: 116/315 - (36%)
• Gaps: 75/315 - (23%)

  Fly    11 RRIKPILCGGQSLRSLANGATSKLTTIEVDDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIE 74
            :|...||   ..||...:...::...:|....:|:.||  |.|. :|.||:.::..:...:.:.|
Human    17 KRTNTIL---HHLRMSKHTDAAEEVLLEKKGCTGVITL--NRPKFLNALTLNMIRQIYPQLKKWE 76

  Fly    75 SNKSRGL-ILTSSNDKVFSAGLDLNEMLNPDVERLRLFWTRFQDLWL---ALHLCGLPTAAAING 135
            .:....| |:..:..|.|.||.|:..:...:..:.::....|::.::   |:..|..|..|.|:|
Human    77 QDPETFLIIIKGAGGKAFCAGGDIRVISEAEKAKQKIAPVFFREEYMLNNAVGSCQKPYVALIHG 141

  Fly   136 HSPAAGCVLATACEYRV-------MLPNLFIGIHATRFSFVISKWMMNSYQSVLPRRIVERALNQ 193
            .:...|..|:...::||       .:|...||:    |..|...:.       |||.       |
Human   142 ITMGGGVGLSVHGQFRVATEKCLFAMPETAIGL----FPDVGGGYF-------LPRL-------Q 188

  Fly   194 GKL------------------------FASQEALDVGLVDEIACSKEEALSKCAAFIATFDKTNP 234
            |||                        |...|.|.: |.:::...|..:....|:.:..:...:.
Human   189 GKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAM-LEEDLLALKSPSKENIASVLENYHTESK 252

  Fly   235 VARCLTKRMCREPDVRELLQDRAADLKEC-----VDYVTTPLFQEGLCAHLEGLK 284
            :.|          |...:|::....:..|     |:.:...|.|:|....||.||
Human   253 IDR----------DKSFILEEHMDKINSCFSANTVEEIIENLQQDGSSFALEQLK 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4592	NP_609324.2	crotonase-like	43..287	CDD:474030	57/283 (20%)
HIBCH	NP_055177.2	ECH_2	46..376	CDD:465024	57/283 (20%)